ACTZ_DROME
ID ACTZ_DROME Reviewed; 376 AA.
AC P45889; Q9VG37;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 09-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Actin-related protein 1;
DE AltName: Full=Actin-like protein 1;
DE AltName: Full=Actin-like protein 87C;
GN Name=Arp1; Synonyms=Actr87C, Arp87C; ORFNames=CG6174;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Oregon-R;
RX PubMed=8064864; DOI=10.1006/jmbi.1994.1526;
RA Fyrberg C., Ryan L., Kenton M., Fyrberg E.A.;
RT "Genes encoding actin-related proteins of Drosophila melanogaster.";
RL J. Mol. Biol. 241:498-503(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. ARP1 subfamily. {ECO:0000305}.
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DR EMBL; X78488; CAA55240.1; -; mRNA.
DR EMBL; AE014297; AAF54853.1; -; Genomic_DNA.
DR EMBL; AY070666; AAL48137.1; -; mRNA.
DR PIR; S47988; S47988.
DR RefSeq; NP_524331.2; NM_079607.3.
DR AlphaFoldDB; P45889; -.
DR SMR; P45889; -.
DR BioGRID; 66659; 19.
DR DIP; DIP-18643N; -.
DR IntAct; P45889; 2.
DR STRING; 7227.FBpp0082121; -.
DR PaxDb; P45889; -.
DR PRIDE; P45889; -.
DR DNASU; 41566; -.
DR EnsemblMetazoa; FBtr0082652; FBpp0082121; FBgn0011745.
DR GeneID; 41566; -.
DR KEGG; dme:Dmel_CG6174; -.
DR CTD; 41566; -.
DR FlyBase; FBgn0011745; Arp1.
DR VEuPathDB; VectorBase:FBgn0011745; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000155782; -.
DR HOGENOM; CLU_027965_0_1_1; -.
DR InParanoid; P45889; -.
DR OMA; YTTWTGG; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; P45889; -.
DR Reactome; R-DME-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR SignaLink; P45889; -.
DR BioGRID-ORCS; 41566; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Arp1; fly.
DR GenomeRNAi; 41566; -.
DR PRO; PR:P45889; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0011745; Expressed in eye disc (Drosophila) and 40 other tissues.
DR Genevisible; P45889; DM.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008089; P:anterograde axonal transport; IMP:FlyBase.
DR GO; GO:0019896; P:axonal transport of mitochondrion; IMP:FlyBase.
DR GO; GO:0007018; P:microtubule-based movement; IDA:FlyBase.
DR GO; GO:0000278; P:mitotic cell cycle; HMP:FlyBase.
DR GO; GO:0008090; P:retrograde axonal transport; IMP:FlyBase.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..376
FT /note="Actin-related protein 1"
FT /id="PRO_0000089063"
FT CONFLICT 261..262
FT /note="VL -> AV (in Ref. 1; CAA55240)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 376 AA; 42719 MW; EC7ACFE7A5F99962 CRC64;
MEPYDVVVNQ PVVIDNGSGV IKAGFAGEHI PKCRFPNYIG RPKHVRVMAG ALEGDIFVGP
KAEEHRGLLS IRYPMEHGIV TDWNDMERIW SYIYSKEQLA TFTEDHPVLL TEAPLNPRRN
REKAAEFFFE GINAPALFVS MQAVLSLYAT GRVTGVVLDS GDGVTHAVPI YEGFAMPHSI
MRVDIAGRDV TRYLKTLIRR EGFNFRSTAE FEIVRSIKEK VCYLATNPQK EETVETEKFA
YKLPDGKIFE IGPARFRAPE VLFRPDLLGE ECEGIHDVLM YSIEKSDMDL RKMLYQNIVL
SGGSTLFKGF GDRLLSELKK HSAKDLKIRI AAPQERLYST WMGGSILASL DTFKKMWISK
REYEEEGQKA VHRKTF
