ID   C_PI3H4                 Reviewed;         199 AA.
AC   P06165;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   23-FEB-2022, entry version 57.
DE   RecName: Full=Protein C;
DE   AltName: Full=VP18 protein;
GN   Name=P/V/C;
OS   Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human
OS   parainfluenza 3 virus (strain NIH 47885)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Respirovirus.
OX   NCBI_TaxID=11217;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3016995; DOI=10.1016/0042-6822(86)90036-x;
RA   Luk D., Sanchez A., Banerjee A.K.;
RT   "Messenger RNA encoding the phosphoprotein (P) gene of human parainfluenza
RT   virus 3 is bicistronic.";
RL   Virology 153:318-325(1986).
RN   [2]
RP   ERRATUM OF PUBMED:3016995, AND SEQUENCE REVISION.
RA   Luk D., Sanchez A., Banerjee A.K.;
RL   Virology 156:193-194(1987).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3022477; DOI=10.1016/0042-6822(86)90167-4;
RA   Galinski M.S., Mink M.A., Lambert D.M., Wechsler S.L., Pons W.M.;
RT   "Molecular cloning and sequence analysis of the human parainfluenza 3 virus
RT   mRNA encoding the P and C proteins.";
RL   Virology 155:46-60(1986).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3025346; DOI=10.1099/0022-1317-67-12-2705;
RA   Spriggs M.K., Collins P.L.;
RT   "Sequence analysis of the P and C protein genes of human parainfluenza
RT   virus type 3: patterns of amino acid sequence homology among paramyxovirus
RT   proteins.";
RL   J. Gen. Virol. 67:2705-2719(1986).
CC   -!- SIMILARITY: Belongs to the respirovirus protein C family.
CC       {ECO:0000305}.
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DR   EMBL; D00047; BAA00032.1; -; mRNA.
DR   EMBL; X04721; CAA28430.1; -; Genomic_RNA.
DR   EMBL; D10029; BAA00922.1; -; mRNA.
DR   EMBL; M14932; AAA66819.1; -; Genomic_RNA.
DR   EMBL; M14890; AAA46867.1; -; Genomic_RNA.
DR   PIR; B24189; MNNZP4.
DR   PIR; B27010; MNNZP3.
DR   SMR; P06165; -.
DR   PRIDE; P06165; -.
DR   GO; GO:0039563; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; ISS:UniProtKB.
DR   GO; GO:0039564; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002608; Paramyxo_C.
DR   Pfam; PF01692; Paramyxo_C; 1.
PE   2: Evidence at transcript level;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host STAT1 by virus; Inhibition of host STAT2 by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..199
FT                   /note="Protein C"
FT                   /id="PRO_0000142803"
FT   REGION          19..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        93
FT                   /note="K -> N (in Ref. 2 and 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        194..195
FT                   /note="HL -> QM (in Ref. 4; CAA28430)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   199 AA;  23286 MW;  F0159F995512964B CRC64;
     MLKTIKSWIL GKRNQEINQL ISPRPSTSLN SYSAPTPKKT YRKTTQSTQE PSNSAPPSVN
     QKSNQQKQVK KLVDQLTKID SLGHHTNVQQ KQKIEILIRK LYREDLGEEA AQIVELRLWS
     LEESLEASQI LKMEPKTRRI LISMKLERWI RTLLRGKCDN LQMFQARYQE VMSYLQQNKV
     ETVIMEEAWN LSVHLIQDQ