ID   CYBC1_XENTR             Reviewed;         188 AA.
AC   Q0D2D7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Cytochrome b-245 chaperone 1 homolog {ECO:0000305};
DE   AltName: Full=Essential for reactive oxygen species protein {ECO:0000250|UniProtKB:Q3TYS2};
DE            Short=Eros {ECO:0000250|UniProtKB:Q3TYS2};
GN   Name=cybc1; Synonyms=eros {ECO:0000250|UniProtKB:Q3TYS2};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a chaperone necessary for a stable expression of
CC       the CYBA and CYBB subunits of the cytochrome b-245 heterodimer.
CC       {ECO:0000250|UniProtKB:Q9BQA9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BQA9}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CYBC1 family.
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DR   EMBL; BC121946; AAI21947.1; -; mRNA.
DR   RefSeq; NP_001072837.1; NM_001079369.1.
DR   AlphaFoldDB; Q0D2D7; -.
DR   STRING; 8364.ENSXETP00000026727; -.
DR   PaxDb; Q0D2D7; -.
DR   PRIDE; Q0D2D7; -.
DR   DNASU; 780298; -.
DR   Ensembl; ENSXETT00000026727; ENSXETP00000026727; ENSXETG00000012235.
DR   GeneID; 780298; -.
DR   KEGG; xtr:780298; -.
DR   CTD; 79415; -.
DR   Xenbase; XB-GENE-977743; cybc1.
DR   eggNOG; ENOG502S06T; Eukaryota.
DR   HOGENOM; CLU_100734_0_0_1; -.
DR   InParanoid; Q0D2D7; -.
DR   OMA; CKMGYMQ; -.
DR   OrthoDB; 1293240at2759; -.
DR   PhylomeDB; Q0D2D7; -.
DR   TreeFam; TF332389; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012235; Expressed in 2-cell stage embryo and 13 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0045728; P:respiratory burst after phagocytosis; ISS:UniProtKB.
DR   InterPro; IPR027846; Cybc1.
DR   PANTHER; PTHR31837; PTHR31837; 1.
DR   Pfam; PF15169; Cybc1_Eros; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Endoplasmic reticulum; Immunity; Innate immunity; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..188
FT                   /note="Cytochrome b-245 chaperone 1 homolog"
FT                   /id="PRO_0000281423"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   188 AA;  21079 MW;  13D5B3CBA989BF36 CRC64;
     MYMQVESRTG TLLHLKRNPS IRSWSLLVGI SSVGLAAAYY STDTWLWKLF YVAGCAFVAL
     QNLEDWEEAI FDKKSGKAIL ITYSLYKKLL TLCKGGQEQV VVLLKEIRDV NVEEERVRYF
     GSGYVIVLRF VTGISHPLTQ SAVLGARSDV EAVAKELTKF LEFDLVGSRP QAVEESNDSE
     SDEALDTQ