ID   CYBC1_XENLA             Reviewed;         188 AA.
AC   Q5HZS2;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Cytochrome b-245 chaperone 1 homolog {ECO:0000305};
DE   AltName: Full=Essential for reactive oxygen species protein {ECO:0000250|UniProtKB:Q3TYS2};
DE            Short=Eros {ECO:0000250|UniProtKB:Q3TYS2};
GN   Name=cybc1; Synonyms=eros {ECO:0000250|UniProtKB:Q3TYS2};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a chaperone necessary for a stable expression of
CC       the CYBA and CYBB subunits of the cytochrome b-245 heterodimer.
CC       {ECO:0000250|UniProtKB:Q9BQA9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BQA9}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CYBC1 family.
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DR   EMBL; BC088908; AAH88908.1; -; mRNA.
DR   RefSeq; NP_001088943.1; NM_001095474.1.
DR   AlphaFoldDB; Q5HZS2; -.
DR   DNASU; 496319; -.
DR   GeneID; 496319; -.
DR   KEGG; xla:496319; -.
DR   CTD; 496319; -.
DR   Xenbase; XB-GENE-6252094; cybc1.L.
DR   OrthoDB; 1293240at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 496319; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0045728; P:respiratory burst after phagocytosis; ISS:UniProtKB.
DR   InterPro; IPR027846; Cybc1.
DR   PANTHER; PTHR31837; PTHR31837; 1.
DR   Pfam; PF15169; Cybc1_Eros; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Endoplasmic reticulum; Immunity; Innate immunity; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..188
FT                   /note="Cytochrome b-245 chaperone 1 homolog"
FT                   /id="PRO_0000281422"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   188 AA;  21045 MW;  FD615BFDF60716EF CRC64;
     MYMQVESRTG TLLHLKRNPS IRSWSLLVGI LSVGLAAAYY STDTWLWKLF YVAGCAFVAL
     QNLEDWEEAV FDKKSGKAIL TTYSIYKKLL TLCKGGQDQV VVLLKEIRDV NVAEERVRYF
     GKGYVIVLRF VTGISHPLTQ SAVLGARSDV EAVAKELTKF LELDLVRTRS QAVEESSDSE
     SDGALDKQ