ID   CYBC1_RAT               Reviewed;         187 AA.
AC   Q6AYA6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Cytochrome b-245 chaperone 1 {ECO:0000305};
DE   AltName: Full=Essential for reactive oxygen species protein {ECO:0000250|UniProtKB:Q3TYS2};
DE            Short=Eros {ECO:0000250|UniProtKB:Q3TYS2};
GN   Name=Cybc1 {ECO:0000312|RGD:1562022};
GN   Synonyms=Eros {ECO:0000250|UniProtKB:Q3TYS2};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Brown Norway; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-170, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Functions as a chaperone necessary for a stable expression of
CC       the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By
CC       similarity). Controls the phagocyte respiratory burst and is essential
CC       for innate immunity (By similarity). {ECO:0000250|UniProtKB:Q3TYS2,
CC       ECO:0000250|UniProtKB:Q9BQA9}.
CC   -!- SUBUNIT: Interacts with CYBB; CYBC1 may act as a chaperone stabilizing
CC       Cytochrome b-245 heterodimer. {ECO:0000250|UniProtKB:Q9BQA9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BQA9}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CYBC1 family.
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DR   EMBL; BC079126; AAH79126.1; -; mRNA.
DR   RefSeq; NP_001030131.1; NM_001034959.1.
DR   AlphaFoldDB; Q6AYA6; -.
DR   STRING; 10116.ENSRNOP00000051805; -.
DR   iPTMnet; Q6AYA6; -.
DR   PhosphoSitePlus; Q6AYA6; -.
DR   jPOST; Q6AYA6; -.
DR   PaxDb; Q6AYA6; -.
DR   PRIDE; Q6AYA6; -.
DR   Ensembl; ENSRNOT00000054922; ENSRNOP00000051805; ENSRNOG00000036666.
DR   GeneID; 619574; -.
DR   KEGG; rno:619574; -.
DR   CTD; 79415; -.
DR   RGD; 1562022; Cybc1.
DR   eggNOG; ENOG502S06T; Eukaryota.
DR   GeneTree; ENSGT00390000004691; -.
DR   HOGENOM; CLU_100734_0_0_1; -.
DR   InParanoid; Q6AYA6; -.
DR   OMA; IRSWSLC; -.
DR   OrthoDB; 1293240at2759; -.
DR   PhylomeDB; Q6AYA6; -.
DR   TreeFam; TF332389; -.
DR   PRO; PR:Q6AYA6; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000036666; Expressed in spleen and 20 other tissues.
DR   Genevisible; Q6AYA6; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0045728; P:respiratory burst after phagocytosis; ISS:UniProtKB.
DR   InterPro; IPR027846; Cybc1.
DR   PANTHER; PTHR31837; PTHR31837; 1.
DR   Pfam; PF15169; Cybc1_Eros; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Endoplasmic reticulum; Immunity; Innate immunity; Membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..187
FT                   /note="Cytochrome b-245 chaperone 1"
FT                   /id="PRO_0000281420"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          167..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         170
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   187 AA;  20894 MW;  41513AA6A34AAD42 CRC64;
     MYMQVETRTS TRLHLKRAPG IRSWSLLVGI LSTGLAAAYY SGDSLGWKLF YVTGCLFVAV
     QNLEDWEEAI FNKSTGKVIL KTFSLYKKLL TLLRAGHDQV VVLLKDIQDV NVEEEKVRYF
     GKGYMVVLRF ATGFSHPLTQ SAVMGRRSDV EAIAKLITSF LELHRLESPS ERSQSSDSEP
     DGPGGQS