ID   CYBC1_DANRE             Reviewed;         206 AA.
AC   Q6DGA7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Cytochrome b-245 chaperone 1 homolog {ECO:0000305};
DE   AltName: Full=Essential for reactive oxygen species protein {ECO:0000250|UniProtKB:Q3TYS2};
DE            Short=Eros {ECO:0000250|UniProtKB:Q3TYS2};
GN   Name=cybc1 {ECO:0000250|UniProtKB:Q3TYS2};
GN   Synonyms=eros {ECO:0000250|UniProtKB:Q3TYS2}; ORFNames=zgc:91940;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a chaperone necessary for a stable expression of
CC       the CYBA and CYBB subunits of the cytochrome b-245 heterodimer.
CC       {ECO:0000250|UniProtKB:Q9BQA9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BQA9}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CYBC1 family.
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DR   EMBL; BC076444; AAH76444.1; -; mRNA.
DR   RefSeq; NP_001002669.1; NM_001002669.1.
DR   AlphaFoldDB; Q6DGA7; -.
DR   STRING; 7955.ENSDARP00000096339; -.
DR   PaxDb; Q6DGA7; -.
DR   Ensembl; ENSDART00000105562; ENSDARP00000096339; ENSDARG00000071414.
DR   Ensembl; ENSDART00000191738; ENSDARP00000144672; ENSDARG00000111331.
DR   GeneID; 436942; -.
DR   KEGG; dre:436942; -.
DR   CTD; 79415; -.
DR   ZFIN; ZDB-GENE-040718-418; cybc1.
DR   eggNOG; ENOG502S06T; Eukaryota.
DR   GeneTree; ENSGT00390000004691; -.
DR   HOGENOM; CLU_100734_0_0_1; -.
DR   InParanoid; Q6DGA7; -.
DR   OMA; IRSWSLC; -.
DR   OrthoDB; 1293240at2759; -.
DR   PhylomeDB; Q6DGA7; -.
DR   TreeFam; TF332389; -.
DR   PRO; PR:Q6DGA7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000071414; Expressed in granulocyte and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0045728; P:respiratory burst after phagocytosis; ISS:UniProtKB.
DR   InterPro; IPR027846; Cybc1.
DR   PANTHER; PTHR31837; PTHR31837; 1.
DR   Pfam; PF15169; Cybc1_Eros; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Endoplasmic reticulum; Immunity; Innate immunity; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..206
FT                   /note="Cytochrome b-245 chaperone 1 homolog"
FT                   /id="PRO_0000281421"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          172..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  23376 MW;  E239B3DB90CCF8EF CRC64;
     MGYMIVEKHT SELLHLKRSP GIRSWSILVG IASVGLAAAY YSSDSILWKM FYVTGCFFVA
     LQNMEEWEEA VFNKSKNEIE LKTFSLYTML LTLWKRGHEK VLLDLRHLRD VSVQEERVRY
     LGKGYLVVLR LATGFSYPLT QSATLGSRSD VEALAALLKR FLGLEELQQR LADDDYPDDD
     DGIEDLGLGD SSDSQDDPDG DDDEEH