ID   CYBC1_BOVIN             Reviewed;         187 AA.
AC   Q3SZM3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Cytochrome b-245 chaperone 1 {ECO:0000305};
DE   AltName: Full=Essential for reactive oxygen species protein {ECO:0000250|UniProtKB:Q3TYS2};
DE            Short=Eros {ECO:0000250|UniProtKB:Q3TYS2};
GN   Name=CYBC1 {ECO:0000250|UniProtKB:Q3TYS2};
GN   Synonyms=EROS {ECO:0000250|UniProtKB:Q3TYS2};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a chaperone necessary for a stable expression of
CC       the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By
CC       similarity). Controls the phagocyte respiratory burst and is essential
CC       for innate immunity (By similarity). {ECO:0000250|UniProtKB:Q3TYS2,
CC       ECO:0000250|UniProtKB:Q9BQA9}.
CC   -!- SUBUNIT: Interacts with CYBB; CYBC1 may act as a chaperone stabilizing
CC       Cytochrome b-245 heterodimer. {ECO:0000250|UniProtKB:Q9BQA9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BQA9}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CYBC1 family.
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DR   EMBL; BC102788; AAI02789.1; -; mRNA.
DR   RefSeq; NP_001071555.1; NM_001078087.2.
DR   RefSeq; XP_005221126.1; XM_005221069.3.
DR   RefSeq; XP_005221127.1; XM_005221070.3.
DR   AlphaFoldDB; Q3SZM3; -.
DR   STRING; 9913.ENSBTAP00000024188; -.
DR   PaxDb; Q3SZM3; -.
DR   Ensembl; ENSBTAT00000024188; ENSBTAP00000024188; ENSBTAG00000018176.
DR   Ensembl; ENSBTAT00000078853; ENSBTAP00000056820; ENSBTAG00000018176.
DR   GeneID; 618343; -.
DR   KEGG; bta:618343; -.
DR   CTD; 79415; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018176; -.
DR   VGNC; VGNC:52655; CYBC1.
DR   eggNOG; ENOG502S06T; Eukaryota.
DR   GeneTree; ENSGT00390000004691; -.
DR   HOGENOM; CLU_100734_0_0_1; -.
DR   InParanoid; Q3SZM3; -.
DR   OMA; IRSWSLC; -.
DR   OrthoDB; 1293240at2759; -.
DR   TreeFam; TF332389; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000018176; Expressed in nasopharynx and 107 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0045728; P:respiratory burst after phagocytosis; ISS:UniProtKB.
DR   InterPro; IPR027846; Cybc1.
DR   PANTHER; PTHR31837; PTHR31837; 1.
DR   Pfam; PF15169; Cybc1_Eros; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Endoplasmic reticulum; Immunity; Innate immunity; Membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..187
FT                   /note="Cytochrome b-245 chaperone 1"
FT                   /id="PRO_0000281417"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AYA6"
SQ   SEQUENCE   187 AA;  20905 MW;  FEF1FAF3D01B5570 CRC64;
     MYMQVETRTS SRLHLKRAPG IRSWSLLVGI LSIGLAAAYY SGDSLGWKLF YVTGCLFVAV
     QNLEDWEEAI FNKSTGKVVL KTFSLYRKLL TLCRAGHDQV VVLLSDIRDV NVEEEKVRYF
     GKGYVVVLRF ATGFSHPLTQ SAVMGHRSDV EVIAKLITTF LELHRLESPV ELSQSSDSEA
     DSPGDQS