ID   CXG1_BOVIN              Reviewed;         396 AA.
AC   Q2HJ66;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Gap junction gamma-1 protein;
DE   AltName: Full=Gap junction alpha-7 protein;
GN   Name=GJC1; Synonyms=GJA7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC       with CNST (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC113285; AAI13286.1; -; mRNA.
DR   RefSeq; NP_001039541.1; NM_001046076.1.
DR   RefSeq; XP_005220906.1; XM_005220849.3.
DR   RefSeq; XP_005220907.1; XM_005220850.3.
DR   RefSeq; XP_005220908.1; XM_005220851.3.
DR   RefSeq; XP_010814634.1; XM_010816332.2.
DR   RefSeq; XP_010814635.1; XM_010816333.2.
DR   RefSeq; XP_015314351.1; XM_015458865.1.
DR   AlphaFoldDB; Q2HJ66; -.
DR   SMR; Q2HJ66; -.
DR   STRING; 9913.ENSBTAP00000005277; -.
DR   PaxDb; Q2HJ66; -.
DR   Ensembl; ENSBTAT00000005277; ENSBTAP00000005277; ENSBTAG00000004036.
DR   GeneID; 511119; -.
DR   KEGG; bta:511119; -.
DR   CTD; 10052; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004036; -.
DR   VGNC; VGNC:29382; GJC1.
DR   eggNOG; ENOG502QV2G; Eukaryota.
DR   GeneTree; ENSGT01050000244833; -.
DR   HOGENOM; CLU_037388_0_0_1; -.
DR   InParanoid; Q2HJ66; -.
DR   OMA; VRWKQHR; -.
DR   OrthoDB; 692491at2759; -.
DR   TreeFam; TF329606; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000004036; Expressed in oocyte and 96 other tissues.
DR   ExpressionAtlas; Q2HJ66; baseline and differential.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002265; Connexin45.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01136; CONNEXINA6.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..396
FT                   /note="Gap junction gamma-1 protein"
FT                   /id="PRO_0000244877"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..175
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..228
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..396
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          146..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  45553 MW;  C3BE7424F9AFB489 CRC64;
     MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC
     ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGDADKK AARSKPYAMR
     WKQHRALEET EEDHEEDPMM YPEMELESEK ENKDQNQSKP KHDGRRRIRE DGLMKIYVLQ
     LLARTVFEVG FLVGQYFLYG FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG
     LCLLLNIWEM LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
     YTELSNAKIA YKQNKANIAQ EQQYGSHEDN LPPDLETLQR EIRMAQERLD LAIQAYNHQN
     NPHGSREKKA KVGSKAGSNK SSASSKSGDG KTSVWI