ID   CXD2_BOVIN              Reviewed;         321 AA.
AC   Q866T7;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Gap junction delta-2 protein;
DE   AltName: Full=Connexin-36;
DE            Short=Cx36;
DE   AltName: Full=Gap junction alpha-9 protein;
GN   Name=GJD2; Synonyms=GJA9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Singh V., Pulukuri S., Duda T., Venkataraman V., Mitton K.P.,
RA   Sitaramayya A.;
RT   "Bovine connexin-36 (CX36) mRNA.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- SIMILARITY: Belongs to the connexin family. Delta-type subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY150575; AAN37413.1; -; mRNA.
DR   RefSeq; NP_777108.1; NM_174683.1.
DR   AlphaFoldDB; Q866T7; -.
DR   SMR; Q866T7; -.
DR   STRING; 9913.ENSBTAP00000028966; -.
DR   PaxDb; Q866T7; -.
DR   PeptideAtlas; Q866T7; -.
DR   Ensembl; ENSBTAT00000028966; ENSBTAP00000028966; ENSBTAG00000021730.
DR   GeneID; 282577; -.
DR   KEGG; bta:282577; -.
DR   CTD; 57369; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021730; -.
DR   VGNC; VGNC:29385; GJD2.
DR   eggNOG; ENOG502QV4X; Eukaryota.
DR   GeneTree; ENSGT01050000244833; -.
DR   HOGENOM; CLU_037388_4_0_1; -.
DR   InParanoid; Q866T7; -.
DR   OMA; KEMEPDC; -.
DR   OrthoDB; 872373at2759; -.
DR   TreeFam; TF329606; -.
DR   Reactome; R-BTA-112303; Electric Transmission Across Gap Junctions.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000021730; Expressed in retina and 13 other tissues.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; ISS:AgBase.
DR   GO; GO:0007268; P:chemical synaptic transmission; ISS:AgBase.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0007601; P:visual perception; ISS:AgBase.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002260; Connexin36.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01131; CONNEXIN36.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..321
FT                   /note="Gap junction delta-2 protein"
FT                   /id="PRO_0000057834"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..197
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..252
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        276..321
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          117..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   321 AA;  36126 MW;  9DD220A10767AB17 CRC64;
     MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILIVAI VGETVYDDEQ TMFVCNTLQP
     GCNQACYDRA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ SAKQRERRYS TVFLALDRDP
     PESMGGPGGT GGGGSGGGKR EDKKLQNAIV NGVLQNTENT SKETEPDCLE VKELTPHPSG
     LRTASRSKLR RQEGISRFYI IQVVFRNALE IGFLVGQYFL YGFSVPGLYE CDRYPCIKEV
     ECYVSRPTEK TVFLVFMFAV SGICVVLNLA ELNHLGWRKI KLAVRGAQAK RKSVYEIRNK
     DLPRVSVPNF GRTQSSDSAY V