ID   CWC22_MAGO7             Reviewed;         907 AA.
AC   Q52B63; A4RM83; G4MUM6;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Pre-mRNA-splicing factor CWC22;
GN   Name=CWC22; ORFNames=MGG_10180;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR   EMBL; CM001232; EHA53999.1; -; Genomic_DNA.
DR   RefSeq; XP_003713806.1; XM_003713758.1.
DR   AlphaFoldDB; Q52B63; -.
DR   SMR; Q52B63; -.
DR   STRING; 318829.MGG_10180T0; -.
DR   PRIDE; Q52B63; -.
DR   EnsemblFungi; MGG_10180T0; MGG_10180T0; MGG_10180.
DR   GeneID; 2681807; -.
DR   KEGG; mgr:MGG_10180; -.
DR   VEuPathDB; FungiDB:MGG_10180; -.
DR   eggNOG; KOG2140; Eukaryota.
DR   HOGENOM; CLU_006308_0_2_1; -.
DR   InParanoid; Q52B63; -.
DR   OMA; NIFKFDA; -.
DR   OrthoDB; 996017at2759; -.
DR   Proteomes; UP000009058; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02847; MA3; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51366; MI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..907
FT                   /note="Pre-mRNA-splicing factor CWC22"
FT                   /id="PRO_0000215673"
FT   DOMAIN          159..342
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   DOMAIN          444..560
FT                   /note="MI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   REGION          1..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..907
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..94
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..422
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..675
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        687..764
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        830..848
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        883..907
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   907 AA;  102101 MW;  56F5F6D5721952F5 CRC64;
     MSSPDARDAR SPSPRPRSPS PAAPSRSWSR SRHESPSRSP APMRERREEE GNEQRSPRQI
     AHHPRSPRGS DRRAEPRRRD AGGGGGDKYR PAKARKQRSP PPAATEEQKQ AAAKAEYERL
     LTARSGGTYV PPARLRALQA QITDKTSMAY QRMAWDALKK SINGLINKVN VSNIKPLVPE
     LFNENLVRGR GLFCQSAIKA QAASLPFTPI YAALVAVVNT KLPQVGELLL RRLVLRFRKA
     FRRNDKAVCL SATTFVAHLV NQQVAHEMVA GQMLLLLLNK PTDDSVEIAV GLTREVGQFL
     EEMNAAIANV VFDRFRDILH EADIAKRTQY MIEVLFQTRK DRFKDNPAIR DELDLVEEDD
     QIKHFVELDG ELDAQDGLNI FKFDPEYEEN EEKYKKLKAE ILGEGSDYED DSDDEGSDSS
     DDEPAAAEQK AMDIQDRSNA DLVALRRTIY LTLMSSMDPE EAVHKLMKIN LPQGLEGELP
     SLVVESCAQE RTYSKFYGAI GERLAKINRL WTDLFEKSFE HYYTSIHRYE TNRLRNIARF
     FGHMFSSDAI GWHCLSVIHL NEEETTSASR IFIKILFQEI SEAMGMPKLH TRTKDAALQP
     YMEGLFPRDT ARNIRFSINY FTSIGMGVLT EDSREFLQNM PKPALPAPPP DSDSESSSSY
     SSYTGSSYSR SRSPSPRRRS YSRSRSRSVT PRRTNSNGRN NARSPSRSVS RSISRSRSPA
     PIRGRSYSRS VSRSRSRSYS RSVSRSPTPP RRQAPAQQRG RQRSYTPSDR SRSRSYSRSR
     SPRGRSYTRS PDRAGPQAST APRSGGPPRK AGSVDNRSPL SRSPSGSRSP SPRRRRDSPS
     RSPVRDRESG GRAAAAAPGN SEARRGRSYS RSPSRTRSPS PAPSRRRRRD SSSDASAPRK
     RRRESSR