CUL2_ARATH
ID CUL2_ARATH Reviewed; 742 AA.
AC Q9SRZ0; Q8GY26;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Cullin-2;
DE Short=AtCUL1;
GN Name=CUL2; OrderedLocusNames=At1g02980; ORFNames=F22D16.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-742.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 475-742.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP INTERACTION WITH SKIP17 AND SKIP18.
RX PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT Arabidopsis.";
RL Plant J. 34:753-767(2003).
CC -!- FUNCTION: Core component of multiple SCF (SKP1-CUL1-F-box protein) E3
CC ubiquitin-protein ligase complexes. Involved in ubiquitination and
CC subsequent proteasomal degradation of target proteins (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SKIP17 and FBW2/SKIP18.
CC {ECO:0000269|PubMed:12795696}.
CC -!- PTM: Neddylated; which enhances the ubiquitination activity of E3
CC ubiquitin-protein ligase complexes. {ECO:0000250|UniProtKB:Q13617,
CC ECO:0000250|UniProtKB:Q9D4H8}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00330}.
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DR EMBL; AC009525; AAF02868.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27509.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59352.1; -; Genomic_DNA.
DR EMBL; AK117909; BAC42547.1; -; mRNA.
DR EMBL; BT006231; AAP12880.1; -; mRNA.
DR PIR; D86160; D86160.
DR RefSeq; NP_001318910.1; NM_001331372.1.
DR RefSeq; NP_171797.2; NM_100179.4.
DR AlphaFoldDB; Q9SRZ0; -.
DR SMR; Q9SRZ0; -.
DR BioGRID; 24650; 2.
DR ComplexPortal; CPX-1471; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A.
DR ComplexPortal; CPX-1472; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B.
DR ComplexPortal; CPX-1473; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3.
DR ComplexPortal; CPX-1474; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4.
DR ComplexPortal; CPX-1475; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5.
DR ComplexPortal; CPX-1476; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK6.
DR ComplexPortal; CPX-1477; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK7.
DR ComplexPortal; CPX-1478; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK8.
DR ComplexPortal; CPX-1479; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK9.
DR ComplexPortal; CPX-1480; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK10.
DR ComplexPortal; CPX-1481; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK11.
DR ComplexPortal; CPX-1482; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK12.
DR ComplexPortal; CPX-1483; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK13.
DR ComplexPortal; CPX-1484; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK14.
DR ComplexPortal; CPX-1485; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK15.
DR ComplexPortal; CPX-1486; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK16.
DR ComplexPortal; CPX-1487; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17.
DR ComplexPortal; CPX-1488; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK18.
DR ComplexPortal; CPX-1489; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK19.
DR ComplexPortal; CPX-1490; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK20.
DR ComplexPortal; CPX-1491; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK21.
DR ComplexPortal; CPX-1492; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-SKP1A.
DR ComplexPortal; CPX-1493; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-SKP1B.
DR ComplexPortal; CPX-1494; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK3.
DR ComplexPortal; CPX-1495; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK4.
DR ComplexPortal; CPX-1496; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK5.
DR ComplexPortal; CPX-1497; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK6.
DR ComplexPortal; CPX-1498; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK7.
DR ComplexPortal; CPX-1499; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK8.
DR ComplexPortal; CPX-1502; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK9.
DR ComplexPortal; CPX-1503; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK10.
DR ComplexPortal; CPX-1504; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK11.
DR ComplexPortal; CPX-1505; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK12.
DR ComplexPortal; CPX-1506; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK13.
DR ComplexPortal; CPX-1507; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK14.
DR ComplexPortal; CPX-1508; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK15.
DR ComplexPortal; CPX-1509; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK16.
DR ComplexPortal; CPX-1510; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK17.
DR ComplexPortal; CPX-1511; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK18.
DR ComplexPortal; CPX-1512; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK19.
DR ComplexPortal; CPX-1513; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK20.
DR ComplexPortal; CPX-1514; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK21.
DR ComplexPortal; CPX-1557; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A.
DR ComplexPortal; CPX-1558; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B.
DR ComplexPortal; CPX-1559; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3.
DR ComplexPortal; CPX-1560; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4.
DR ComplexPortal; CPX-1561; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5.
DR ComplexPortal; CPX-1562; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK6.
DR ComplexPortal; CPX-1563; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK7.
DR ComplexPortal; CPX-1564; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK8.
DR ComplexPortal; CPX-1565; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK9.
DR ComplexPortal; CPX-1566; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK10.
DR ComplexPortal; CPX-1567; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK11.
DR ComplexPortal; CPX-1568; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK12.
DR ComplexPortal; CPX-1569; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK13.
DR ComplexPortal; CPX-1570; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK14.
DR ComplexPortal; CPX-1571; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK15.
DR ComplexPortal; CPX-1572; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK16.
DR ComplexPortal; CPX-1573; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17.
DR ComplexPortal; CPX-1574; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK18.
DR ComplexPortal; CPX-1575; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK19.
DR ComplexPortal; CPX-1576; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK20.
DR ComplexPortal; CPX-1577; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK21.
DR ComplexPortal; CPX-1578; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-SKP1A.
DR ComplexPortal; CPX-1579; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-SKP1B.
DR ComplexPortal; CPX-1580; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK3.
DR ComplexPortal; CPX-1581; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK4.
DR ComplexPortal; CPX-1582; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK5.
DR ComplexPortal; CPX-1583; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK6.
DR ComplexPortal; CPX-1584; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK7.
DR ComplexPortal; CPX-1585; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK8.
DR ComplexPortal; CPX-1586; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK9.
DR ComplexPortal; CPX-1587; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK10.
DR ComplexPortal; CPX-1588; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK11.
DR ComplexPortal; CPX-1589; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK12.
DR ComplexPortal; CPX-1590; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK13.
DR ComplexPortal; CPX-1591; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK14.
DR ComplexPortal; CPX-1592; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK15.
DR ComplexPortal; CPX-1593; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK16.
DR ComplexPortal; CPX-1594; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK17.
DR ComplexPortal; CPX-1595; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK18.
DR ComplexPortal; CPX-1596; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK19.
DR ComplexPortal; CPX-1597; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK20.
DR ComplexPortal; CPX-1598; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK21.
DR STRING; 3702.AT1G02980.1; -.
DR iPTMnet; Q9SRZ0; -.
DR PaxDb; Q9SRZ0; -.
DR PRIDE; Q9SRZ0; -.
DR ProteomicsDB; 220461; -.
DR EnsemblPlants; AT1G02980.1; AT1G02980.1; AT1G02980.
DR EnsemblPlants; AT1G02980.2; AT1G02980.2; AT1G02980.
DR GeneID; 839415; -.
DR Gramene; AT1G02980.1; AT1G02980.1; AT1G02980.
DR Gramene; AT1G02980.2; AT1G02980.2; AT1G02980.
DR KEGG; ath:AT1G02980; -.
DR Araport; AT1G02980; -.
DR TAIR; locus:2024755; AT1G02980.
DR eggNOG; KOG2166; Eukaryota.
DR HOGENOM; CLU_004747_3_0_1; -.
DR InParanoid; Q9SRZ0; -.
DR OMA; NCAYHEA; -.
DR OrthoDB; 1040292at2759; -.
DR PhylomeDB; Q9SRZ0; -.
DR PRO; PR:Q9SRZ0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SRZ0; baseline and differential.
DR Genevisible; Q9SRZ0; AT.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:TAIR.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IC:ComplexPortal.
DR GO; GO:0009867; P:jasmonic acid mediated signaling pathway; IMP:ComplexPortal.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0009733; P:response to auxin; IC:ComplexPortal.
DR GO; GO:0009753; P:response to jasmonic acid; IMP:ComplexPortal.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; PTHR11932; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
DR SUPFAM; SSF75632; SSF75632; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Reference proteome; Ubl conjugation;
KW Ubl conjugation pathway.
FT CHAIN 1..742
FT /note="Cullin-2"
FT /id="PRO_0000396848"
FT CROSSLNK 686
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in NEDD8)"
FT /evidence="ECO:0000250|UniProtKB:Q13616"
SQ SEQUENCE 742 AA; 85965 MW; 453EF10CDA6A82F8 CRC64;
MAKKDSVLEA GWSVMEAGVA KLQKILEEVP DEPPFDPVQR MQLYTTVHNL CTQKPPNDYS
QQIYDRYGGV YVDYNKQTVL PAIREKHGEY MLRELVKRWA NQKILVRWLS HFFEYLDRFY
TRRGSHPTLS AVGFISFRDL VYQELQSKAK DAVLALIHKE REGEQIDRAL LKNVIDVYCG
NGMGELVKYE EDFESFLLED SASYYSRNAS RWNQENSCPD YMIKAEESLR LEKERVTNYL
HSTTEPKLVA KVQNELLVVV AKQLIENEHS GCRALLRDDK MDDLARMYRL YHPIPQGLDP
VADLFKQHIT VEGSALIKQA TEAATDKAAS TSGLKVQDQV LIRQLIDLHD KFMVYVDECF
QKHSLFHKAL KEAFEVFCNK TVAGVSSAEI LATYCDNILK TGGGIEKLEN EDLELTLEKV
VKLLVYISDK DLFAEFFRKK QARRLLFDRN GNDYHERSLL TKFKELLGAQ FTSKMEGMLT
DMTLAKEHQT NFVEFLSVNK TKKLGMDFTV TVLTTGFWPS YKTTDLNLPI EMVNCVEAFK
AYYGTKTNSR RLSWIYSLGT CQLAGKFDKK TIEIVVTTYQ AAVLLLFNNT ERLSYTEILE
QLNLGHEDLA RLLHSLSCLK YKILIKEPMS RNISNTDTFE FNSKFTDKMR RIRVPLPPMD
ERKKIVEDVD KDRRYAIDAA LVRIMKSRKV LGHQQLVSEC VEHLSKMFKP DIKMIKKRIE
DLISRDYLER DTDNPNTFKY LA
