CUE_AEDAE
ID CUE_AEDAE Reviewed; 664 AA.
AC Q16YE7;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Protein cueball {ECO:0000250|UniProtKB:Q95RU0};
DE Flags: Precursor;
GN Name=cue {ECO:0000250|UniProtKB:Q95RU0}; ORFNames=AAEL008564;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:EAT39657.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Has a role in spermatogenesis and oogenesis.
CC {ECO:0000250|UniProtKB:Q95RU0}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cueball family. {ECO:0000305}.
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DR EMBL; CH477517; EAT39657.1; -; Genomic_DNA.
DR RefSeq; XP_001653297.1; XM_001653247.1.
DR AlphaFoldDB; Q16YE7; -.
DR SMR; Q16YE7; -.
DR STRING; 7159.AAEL008564-PA; -.
DR GeneID; 5570793; -.
DR KEGG; aag:5570793; -.
DR VEuPathDB; VectorBase:AAEL008564; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_026602_0_0_1; -.
DR InParanoid; Q16YE7; -.
DR OMA; KLYWTNS; -.
DR OrthoDB; 520442at2759; -.
DR PhylomeDB; Q16YE7; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00135; LY; 5.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
PE 3: Inferred from homology;
KW Cell membrane; Differentiation; Disulfide bond; EGF-like domain;
KW Glycoprotein; Membrane; Oogenesis; Reference proteome; Repeat; Signal;
KW Spermatogenesis; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..664
FT /note="Protein cueball"
FT /evidence="ECO:0000255"
FT /id="PRO_0000386566"
FT TOPO_DOM 22..552
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 574..664
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 115..157
FT /note="LDL-receptor class B 1"
FT /evidence="ECO:0000255"
FT REPEAT 168..211
FT /note="LDL-receptor class B 2"
FT /evidence="ECO:0000255"
FT REPEAT 212..257
FT /note="LDL-receptor class B 3"
FT /evidence="ECO:0000255"
FT DOMAIN 367..399
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 402..438
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 473..510
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 431
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 491
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 551
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 371..380
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 375..390
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 406..416
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 410..426
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 428..437
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 477..487
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 481..498
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 500..509
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 664 AA; 75077 MW; F0169CE54C27EB20 CRC64;
MRNLGIAVTF AVLLVIGYVT ALEWDAVVTT DSGILFFDKN WTQISSGGHQ FHHISAFAYD
EVKRKLYFSD LKDPSFRIFS LDTKPEEEYH KVAKLLPKSD QTGYITGLAF DHLERKLYWT
EKGTHSVYSV EVDKLGAPAN ATDGLINLVA QVEENHDLAA LTIDECRRHL YWTNSYLQTS
SIVRAAMNGT VLDDHKEDVY EPRGISVDHY NNRIYWVEKK YGRAFTVESA NLEVQDRQTF
LRGEDKIPTH VSPNSQYLYW IDQEDGEVHE TMKSDSKVTR VVYKGSRPSA LIIRSGLLVE
YQKNNPSCKA VVSEIIDNVR KESSEVKDVA QAVTSKPEMI TCLNKGILNH NTNSCICLPE
YQGTFCEIPI CNNFCVHGEC VVGADSRPMC KCHAEFEGER CDRNICDGYC LNNGRCALSA
TGQRSCTCSK NFSGARCETA ICTSDYCYNG ECFVENEVPE CKCNVGYRGD RCEEYTCNNY
CLHDGTCILN NDTMLVECRC GSEYTGKRCE IPKRFCSLDN GNPEMQQYCE GVAIAKNLVE
PQVTYCKNSF NRTVVYVSLA FTASLVTLVT ILCTVRRMYE RNRPRITKRF KVTNNTQMTS
RPATQCEITI ENCCNMNVCE TPCFDTKILQ KSATKAEDKQ FLLDDIESIA GSYRKLPSCV
AEKN
