ID   CU01_ANOGA              Reviewed;         245 AA.
AC   Q17015; Q380K4;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 3.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Cuticle protein;
GN   Name=Ccp84Ab; ORFNames=AGAP001666;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-203.
RC   STRAIN=Gasua; TISSUE=Ovary;
RX   PubMed=8807302; DOI=10.1093/genetics/143.3.1307;
RA   della Torre A., Favia G., Mariotti G., Coluzzi M., Mathiopoulos K.D.;
RT   "Physical map of the malaria vector Anopheles gambiae.";
RL   Genetics 143:1307-1311(1996).
CC   -!- FUNCTION: Component of the cuticle of African malaria mosquito.
CC   -!- DOMAIN: The tetrapeptide (A-A-P-[AV]) repeats found throughout the
CC       protein are also present in many proteins constituting the protective
CC       envelope of other species.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA93473.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AAAB01008987; EAL38558.2; -; Genomic_DNA.
DR   EMBL; U50469; AAA93473.1; ALT_FRAME; mRNA.
DR   RefSeq; XP_551139.2; XM_551139.4.
DR   AlphaFoldDB; Q17015; -.
DR   STRING; 7165.AGAP001666-PA; -.
DR   PaxDb; Q17015; -.
DR   GeneID; 3290499; -.
DR   KEGG; aga:AgaP_AGAP001666; -.
DR   CTD; 3290499; -.
DR   VEuPathDB; VectorBase:AGAP001666; -.
DR   eggNOG; ENOG502S21C; Eukaryota.
DR   HOGENOM; CLU_075165_1_0_1; -.
DR   InParanoid; Q17015; -.
DR   OMA; AYNSHAA; -.
DR   OrthoDB; 1544103at2759; -.
DR   PhylomeDB; Q17015; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PRINTS; PR00947; CUTICLE.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   2: Evidence at transcript level;
KW   Cuticle; Reference proteome; Repeat.
FT   CHAIN           1..245
FT                   /note="Cuticle protein"
FT                   /id="PRO_0000196128"
FT   DOMAIN          25..86
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT   REPEAT          92..95
FT                   /note="1"
FT   REPEAT          108..111
FT                   /note="2"
FT   REPEAT          118..121
FT                   /note="3"
FT   REGION          79..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        33
FT                   /note="L -> Y (in Ref. 2; AAA93473)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        65
FT                   /note="H -> Q (in Ref. 2; AAA93473)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        74
FT                   /note="D -> G (in Ref. 2; AAA93473)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88
FT                   /note="S -> D (in Ref. 2; AAA93473)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        196
FT                   /note="P -> T (in Ref. 2; AAA93473)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   245 AA;  25284 MW;  B6604F3256592FF4 CRC64;
     MAFKFVIFAA VVAVARAGLI ASPAVSYAAA PALVAAPVAK VAYAAAPIAK VAYAAQPEEY
     DANPHYSFSY GISDALTGDS KSQQESRSGD VVQGSYSVVD PDGTKRTVDY TADPHNGFNA
     VVRREPLAAK TIVAAAPVAT KVIAQPAVAY AAPVAKTISY AAPVATKTYV AQPALSYAAP
     LTKTYVSQPA LSYAAPVAKT ISYSAPLATK TYVSQPAISY AAPLAKTYVS QPALSYAAPA
     YAYHH