CSRN2_HUMAN
ID CSRN2_HUMAN Reviewed; 543 AA.
AC Q9H175;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Cysteine/serine-rich nuclear protein 2;
DE Short=CSRNP-2;
DE AltName: Full=Protein FAM130A1;
DE AltName: Full=TGF-beta-induced apoptosis protein 12;
DE Short=TAIP-12;
GN Name=CSRNP2; Synonyms=C12orf22, FAM130A1, TAIP12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RA Hene L.;
RL Thesis (2001), University of Oxford, United Kingdom.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Akiyama N., Kondoh S.;
RT "TGF-beta induced apoptosis protein.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Binds to the consensus sequence 5'-AGAGTG-3' and has
CC transcriptional activator activity (By similarity). May play a role in
CC apoptosis. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9H175; P62136: PPP1CA; NbExp=10; IntAct=EBI-5235958, EBI-357253;
CC Q9H175; P62140: PPP1CB; NbExp=7; IntAct=EBI-5235958, EBI-352350;
CC Q9H175; P36873: PPP1CC; NbExp=7; IntAct=EBI-5235958, EBI-356283;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the AXUD1 family. {ECO:0000305}.
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DR EMBL; AJ298133; CAC22252.1; -; mRNA.
DR EMBL; AB063302; BAB79451.2; -; mRNA.
DR EMBL; BC017221; AAH17221.1; -; mRNA.
DR CCDS; CCDS8807.1; -.
DR RefSeq; NP_110436.1; NM_030809.2.
DR RefSeq; XP_006719684.1; XM_006719621.2.
DR AlphaFoldDB; Q9H175; -.
DR BioGRID; 123528; 5.
DR ELM; Q9H175; -.
DR IntAct; Q9H175; 3.
DR MINT; Q9H175; -.
DR STRING; 9606.ENSP00000228515; -.
DR GlyGen; Q9H175; 1 site, 2 O-linked glycans (1 site).
DR iPTMnet; Q9H175; -.
DR PhosphoSitePlus; Q9H175; -.
DR BioMuta; CSRNP2; -.
DR DMDM; 71153583; -.
DR EPD; Q9H175; -.
DR MassIVE; Q9H175; -.
DR PaxDb; Q9H175; -.
DR PeptideAtlas; Q9H175; -.
DR PRIDE; Q9H175; -.
DR ProteomicsDB; 80377; -.
DR Antibodypedia; 14333; 278 antibodies from 29 providers.
DR DNASU; 81566; -.
DR Ensembl; ENST00000228515.6; ENSP00000228515.1; ENSG00000110925.7.
DR GeneID; 81566; -.
DR KEGG; hsa:81566; -.
DR MANE-Select; ENST00000228515.6; ENSP00000228515.1; NM_030809.3; NP_110436.1.
DR UCSC; uc001rxu.3; human.
DR CTD; 81566; -.
DR GeneCards; CSRNP2; -.
DR HGNC; HGNC:16006; CSRNP2.
DR HPA; ENSG00000110925; Low tissue specificity.
DR neXtProt; NX_Q9H175; -.
DR OpenTargets; ENSG00000110925; -.
DR PharmGKB; PA25503; -.
DR VEuPathDB; HostDB:ENSG00000110925; -.
DR eggNOG; KOG3813; Eukaryota.
DR GeneTree; ENSGT00950000183072; -.
DR HOGENOM; CLU_034103_0_1_1; -.
DR InParanoid; Q9H175; -.
DR OMA; CGNVAGR; -.
DR OrthoDB; 577123at2759; -.
DR PhylomeDB; Q9H175; -.
DR TreeFam; TF323969; -.
DR PathwayCommons; Q9H175; -.
DR SignaLink; Q9H175; -.
DR BioGRID-ORCS; 81566; 10 hits in 1084 CRISPR screens.
DR ChiTaRS; CSRNP2; human.
DR GenomeRNAi; 81566; -.
DR Pharos; Q9H175; Tdark.
DR PRO; PR:Q9H175; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9H175; protein.
DR Bgee; ENSG00000110925; Expressed in cortical plate and 182 other tissues.
DR ExpressionAtlas; Q9H175; baseline and differential.
DR Genevisible; Q9H175; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0019902; F:phosphatase binding; IDA:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR031972; CSRNP_N.
DR InterPro; IPR023260; Cys/Ser-rich_nuc_prot.
DR PANTHER; PTHR13580; PTHR13580; 1.
DR Pfam; PF16019; CSRNP_N; 1.
DR PRINTS; PR02031; CYSSERRICHNP.
PE 1: Evidence at protein level;
KW Acetylation; Activator; Apoptosis; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..543
FT /note="Cysteine/serine-rich nuclear protein 2"
FT /id="PRO_0000114790"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT VARIANT 436
FT /note="T -> M (in dbSNP:rs11542510)"
FT /id="VAR_053016"
SQ SEQUENCE 543 AA; 59591 MW; 54C147A9F18C6038 CRC64;
MDAFTGSGLK RKFDDVDVGS SVSNSDDEIS SSDSADSCDS LNPPTTASFT PTSILKRQKQ
LRRKNVRFDQ VTVYYFARRQ GFTSVPSQGG SSLGMAQRHN SVRSYTLCEF AQEQEVNHRE
ILREHLKEEK LHAKKMKLTK NGTVESVEAD GLTLDDVSDE DIDVENVEVD DYFFLQPLPT
KRRRALLRAS GVHRIDAEEK QELRAIRLSR EECGCDCRLY CDPEACACSQ AGIKCQVDRM
SFPCGCSRDG CGNMAGRIEF NPIRVRTHYL HTIMKLELES KRQVSRPAAP DEEPSPTASC
SLTGAQGSET QDFQEFIAEN ETAVMHLQSA EELERLKAEE DSSGSSASLD SSIESLGVCI
LEEPLAVPEE LCPGLTAPIL IQAQLPPGSS VLCFTENSDH PTASTVNSPS YLNSGPLVYY
QVEQRPVLGV KGEPGTEEGS ASFPKEKDLN VFSLPVTSLV ACSSTDPAAL CKSEVGKTPT
LEALLPEDCN PEEPENEDFH PSWSPSSLPF RTDNEEGCGM VKTSQQNEDR PPEDSSLELP
LAV
