ID   CSN9_KLULA              Reviewed;         158 AA.
AC   Q6CQC6;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=COP9 signalosome complex subunit 9;
GN   Name=CSN9; OrderedLocusNames=KLLA0D18139g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the
CC       deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein
CC       ligase complexes. The complex is involved in the regulation of the
CC       mating pheromone response (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382124; CAH00959.1; -; Genomic_DNA.
DR   RefSeq; XP_453863.1; XM_453863.1.
DR   AlphaFoldDB; Q6CQC6; -.
DR   SMR; Q6CQC6; -.
DR   STRING; 28985.XP_453863.1; -.
DR   EnsemblFungi; CAH00959; CAH00959; KLLA0_D18139g.
DR   GeneID; 2893042; -.
DR   KEGG; kla:KLLA0_D18139g; -.
DR   HOGENOM; CLU_138722_0_0_1; -.
DR   InParanoid; Q6CQC6; -.
DR   OMA; FDCRDVY; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; IEA:EnsemblFungi.
DR   GO; GO:0000338; P:protein deneddylation; IEA:EnsemblFungi.
DR   InterPro; IPR016806; Csn9_fungi.
DR   PIRSF; PIRSF022632; UCP022632; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..158
FT                   /note="COP9 signalosome complex subunit 9"
FT                   /id="PRO_0000121019"
FT   DOMAIN          5..119
FT                   /note="PCI"
SQ   SEQUENCE   158 AA;  18361 MW;  D32C3A5F7795BCA3 CRC64;
     MMRELLRNLI EDKTVINYKK WWMECKDAQE TKLLAILCFY DIDDLPEETT AGLDKFVLDK
     LRVLSLLSLC ELSTEVNYQE IKEKCDLKTD GEVEKLLIRA ELFVDLKIDS VARRATVLEY
     KISRDVYSGE KGVPFHTPVR SKINILSALI NWRSSLTD