CRNL1_DICDI
ID CRNL1_DICDI Reviewed; 705 AA.
AC Q54XP4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Crooked neck-like protein 1;
DE AltName: Full=Crooked neck homolog;
GN Name=crnkl1; Synonyms=crn; ORFNames=DDB_G0278819;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing process.
CC {ECO:0000250|UniProtKB:Q9BZJ0}.
CC -!- SUBUNIT: Identified in the spliceosome C complex.
CC {ECO:0000250|UniProtKB:Q9BZJ0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BZJ0}. Nucleus
CC speckle {ECO:0000250|UniProtKB:Q9BZJ0}. Note=Colocalizes with core
CC spliceosomal snRNP proteins. {ECO:0000250|UniProtKB:Q9BZJ0}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; AAFI02000024; EAL68011.1; -; Genomic_DNA.
DR RefSeq; XP_641986.1; XM_636894.1.
DR AlphaFoldDB; Q54XP4; -.
DR SMR; Q54XP4; -.
DR STRING; 44689.DDB0233480; -.
DR PaxDb; Q54XP4; -.
DR EnsemblProtists; EAL68011; EAL68011; DDB_G0278819.
DR GeneID; 8621718; -.
DR KEGG; ddi:DDB_G0278819; -.
DR dictyBase; DDB_G0278819; -.
DR eggNOG; KOG1915; Eukaryota.
DR HOGENOM; CLU_011554_1_0_1; -.
DR InParanoid; Q54XP4; -.
DR OMA; HIKVWIS; -.
DR PhylomeDB; Q54XP4; -.
DR Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:Q54XP4; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0000245; P:spliceosomal complex assembly; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR Pfam; PF02184; HAT; 1.
DR SMART; SM00386; HAT; 14.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..705
FT /note="Crooked neck-like protein 1"
FT /id="PRO_0000328141"
FT REPEAT 55..87
FT /note="HAT 1"
FT REPEAT 89..121
FT /note="HAT 2"
FT REPEAT 123..155
FT /note="HAT 3"
FT REPEAT 157..188
FT /note="HAT 4"
FT REPEAT 190..221
FT /note="HAT 5"
FT REPEAT 223..258
FT /note="HAT 6"
FT REPEAT 260..294
FT /note="HAT 7"
FT REPEAT 304..336
FT /note="HAT 8"
FT REPEAT 338..372
FT /note="HAT 9"
FT REPEAT 382..418
FT /note="HAT 10"
FT REPEAT 420..451
FT /note="HAT 11"
FT REPEAT 453..485
FT /note="HAT 12"
FT REPEAT 487..521
FT /note="HAT 13"
FT REPEAT 523..554
FT /note="HAT 14"
FT REPEAT 597..629
FT /note="HAT 15"
FT REGION 559..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 84720 MW; 939249234BF663D8 CRC64;
MNQNRTGGVS KVKNKSAAPV QITAEQILRV AHENQQTLPK APPKQVITDQ EELEDYRLRK
RQQYESLLGR NRKTAAIYIK YAAWEESQKD LTRARSVFER FLDIDHRIPT VWIKYAEMEM
KNKNINLARN IWDRAVCLLP RVSQLWFKYT FMEDMLGNYP AARAIFERWM QWKPEPQAWN
SYLKFEQRLK LFENTRLIFE KYILVHPYIK TWIKYTKFEE RLGNIENART IFQRAIEFLG
EDGNDEQLFI AFAKFEEKYK EIERARVIYK YAIDHVPKSR AKDLFDTFTN FEKQHGDRIG
IEDVVLGKKR FQYEEEIKKN SKNYDIWFDY LKMEEINGEI EKTREIYERS IGNLPPTNEK
KHWKRYIYLW INYALFEELI SKDMERARSV YSECIKLIPH KEFSFSKIWI LYANFEIRQL
NLDKARLIYG QAIGRNPKSK IFDQYIHLEI ELGNFDRVRT LYEKYLEIMP DNCDAWCKFA
QLETELGETV RARAIFELAI QQPNLDRPEV VWKDFIDSEI QLKQFDFVKQ LYRKLLEKTN
HVKVWIGFIK FVHSIKDKQQ QKQRQQQQEE DGDSNTTKKD GGDDDNNDDI NKPTREIFIE
AHKSLSNSDK EERLLLLESW KEFEQTFGNQ ETLNQVLKKI PQRVIKRRSD GNGGIEEYFD
YIFPEEEKST QTSLKLLEAA QRWKKLKQQQ ELQKQQELQK QQQDS
