ID   CRM_DROSE               Reviewed;         975 AA.
AC   Q8MX88;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Protein cramped;
GN   Name=crm;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=s2;
RX   PubMed=12351680; DOI=10.1073/pnas.202336899;
RA   Harr B., Kauer M., Schloetterer C.;
RT   "Hitchhiking mapping: a population-based fine-mapping strategy for adaptive
RT   mutations in Drosophilamelanogaster.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12949-12954(2002).
CC   -!- FUNCTION: Polycomb group (Pc-G) genes are needed to maintain expression
CC       patterns of the homeotic selector genes of the Antennapedia (Antp-C)
CC       and Bithorax (Bx-C) complexes, and hence for the maintenance of
CC       segmental determination. Can act as a modifier of position effect
CC       variegation (PEV) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
CC       Note=During S-phase in early embryogenesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cramped family. {ECO:0000305}.
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DR   EMBL; AF365399; AAN04294.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8MX88; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007379; P:segment specification; ISS:UniProtKB.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   SMART; SM00717; SANT; 1.
DR   PROSITE; PS51293; SANT; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..975
FT                   /note="Protein cramped"
FT                   /id="PRO_0000197139"
FT   DOMAIN          109..173
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          71..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          809..844
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..425
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        816..842
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   975 AA;  107014 MW;  CBDDC9DF5A814B5D CRC64;
     MEELCKQPPP PPPLPPPPSS PSVAIEDPLP NGKGGGAVVV PSIAKLPEEE LLGSVTMHNC
     PGTRASARVI QKMKQDQTRP MTPPPSEREP NKKEEKAAQK TPSQLKTGSG KTTWTNVERN
     CFFDALNEFG KDFEAVANCI NAKLKRRNAN SDYSFKTKDQ VRQHYYQTYH KICKYVRFSE
     ELKKPAQELY TLINYGEMRR KLQFLTEKHF MKLKQLVYQG QITVRCKGKN IRIKTPSCKA
     LRRLNQLDDS LEDIRLPSKV EVLVTPANME AFGRVQSLAQ NPRGRIIVPL HKKLISFIKT
     FEYKWRSANQ RLHEEKSAIF PSSLPSTATN NNNNNNETEP MQPSVASLDP SMCFQPRPGV
     AIHRPLLSIT AYLSSISICL TAYEERMGFK VRSETLGNLA GMPVAASKRL RTESGSEKRS
     PETKKPKPSA SPPLEKTLDD GPLEGNLMKM ENSSGDELAE EIHEFLGDIL EAMPHPQAVT
     IPALSTTTGD TTTVAVALET SHDPVLQAYP ASADLSHAMV TSVIQTTCAA APAPSTLVSG
     SLTAPSVARS KRKEAKEAAA AAQARNFKPL LSDDILKRIR KGWTQANAAD ITIGDLYVVF
     GQDSKLELEY YWCEVDSSTA MASSILTINT VAPSSSSVAT QTGTSASNAI QTSASSNCYV
     SATSTSSTSL PYNPNDCDSV ERVRAVTTSS VSNKLKHLLL VANLSERVRK RQCNCGHTCD
     RKRDLMTKAQ QLAEATATGV VDGNFRTPML PVRRPISNID PVRQLSALTR QKINRQVLVQ
     RRLLPPTSVG DRPYDLLSVR QLHSGLFEPI DRVDGTSSGG ISSSGSKPDS SMGATAASQD
     QEPGDQRALD FLNDEATQAS NRDMPNLDIC VATSRTDVSG SLNEAVQDES TNQSFFHGSM
     SPMHLLRDST SNARWLEDNI NDFSLTSLLG HLDEIDATRD ILDPSSSMSI ISESSVDFRH
     KFQEIAALLQ QQEKD