ID   CRIP2_RAT               Reviewed;         208 AA.
AC   P36201;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Cysteine-rich protein 2;
DE            Short=CRP-2;
DE   AltName: Full=Protein ESP1;
GN   Name=Crip2; Synonyms=Crp2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Brain;
RX   PubMed=8224170; DOI=10.1016/0014-5793(93)80373-3;
RA   Okano I., Yamamoto T., Kaji A., Kimura T., Mizuno K., Nakamura T.;
RT   "Cloning of CRP2, a novel member of the cysteine-rich protein family with
RT   two repeats of an unusual LIM/double zinc-finger motif.";
RL   FEBS Lett. 333:51-55(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with TGFB1I1. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed more abundantly in liver and kidney of
CC       females than that of males. Equally expressed in brain, lung and heart.
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DR   EMBL; D17512; BAA04464.1; -; mRNA.
DR   EMBL; BC061774; AAH61774.1; -; mRNA.
DR   PIR; S38745; S38745.
DR   RefSeq; NP_071946.1; NM_022501.1.
DR   AlphaFoldDB; P36201; -.
DR   IntAct; P36201; 3.
DR   STRING; 10116.ENSRNOP00000006804; -.
DR   iPTMnet; P36201; -.
DR   PhosphoSitePlus; P36201; -.
DR   jPOST; P36201; -.
DR   PaxDb; P36201; -.
DR   PRIDE; P36201; -.
DR   Ensembl; ENSRNOT00000006804; ENSRNOP00000006804; ENSRNOG00000005041.
DR   GeneID; 338401; -.
DR   KEGG; rno:338401; -.
DR   UCSC; RGD:1302959; rat.
DR   CTD; 1397; -.
DR   RGD; 1302959; Crip2.
DR   eggNOG; KOG1700; Eukaryota.
DR   GeneTree; ENSGT00940000158683; -.
DR   HOGENOM; CLU_054591_2_0_1; -.
DR   InParanoid; P36201; -.
DR   OMA; YEKPCAE; -.
DR   OrthoDB; 1214165at2759; -.
DR   PhylomeDB; P36201; -.
DR   TreeFam; TF313758; -.
DR   PRO; PR:P36201; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000005041; Expressed in heart and 19 other tissues.
DR   Genevisible; P36201; RN.
DR   GO; GO:0005938; C:cell cortex; ISO:RGD.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030097; P:hemopoiesis; ISO:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; LIM domain; Metal-binding; Phosphoprotein; Reference proteome;
KW   Repeat; Zinc.
FT   CHAIN           1..208
FT                   /note="Cysteine-rich protein 2"
FT                   /id="PRO_0000075713"
FT   DOMAIN          5..57
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          126..178
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   MOD_RES         23
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DCT8"
FT   MOD_RES         104
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P52943"
FT   MOD_RES         138
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P52943"
FT   MOD_RES         144
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DCT8"
SQ   SEQUENCE   208 AA;  22696 MW;  6F3B5F8A8FBBAD19 CRC64;
     MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCNKTLT PGGHAEHDGK PFCHKPCYAT
     LFGPKGVNIG GAGSYIYEKP PTEAPQVTGP IEVPVVRTEE RKTSGPPKGP SKASSVTTFT
     GEPNMCPRCN KRVYFAEKVT SLGKDWHRPC LRCERCSKTL TPGGHAEHDG QPYCHKPCYG
     ILFGPKGVNT GAVGSYIYDK DPEGTVQP