ID   CPKA_PYRAB              Reviewed;         314 AA.
AC   Q9UWF8; G8ZI47;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Carbamate kinase;
DE            EC=2.7.2.2;
DE   AltName: Full=Carbamate kinase-like carbamoylphosphate synthase;
GN   Name=cpkA; Synonyms=cpa; OrderedLocusNames=PYRAB08820; ORFNames=PAB0593;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=11523892; DOI=10.1007/s007920100201;
RA   Purcarea C., Herve G., Cunin R., Evans D.R.;
RT   "Cloning, expression, and structure analysis of carbamate kinase-like
RT   carbamoyl phosphate synthetase from Pyrococcus abyssi.";
RL   Extremophiles 5:229-239(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC         H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the carbamate kinase family. {ECO:0000305}.
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DR   EMBL; AF081680; AAF23075.1; -; Genomic_DNA.
DR   EMBL; AJ248285; CAB49796.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70288.1; -; Genomic_DNA.
DR   PIR; C75135; C75135.
DR   RefSeq; WP_010868005.1; NC_000868.1.
DR   AlphaFoldDB; Q9UWF8; -.
DR   SMR; Q9UWF8; -.
DR   STRING; 272844.PAB0593; -.
DR   EnsemblBacteria; CAB49796; CAB49796; PAB0593.
DR   GeneID; 1496232; -.
DR   KEGG; pab:PAB0593; -.
DR   PATRIC; fig|272844.11.peg.932; -.
DR   eggNOG; arCOG00863; Archaea.
DR   HOGENOM; CLU_076278_0_0_2; -.
DR   OMA; QPMDVAG; -.
DR   OrthoDB; 77437at2157; -.
DR   PhylomeDB; Q9UWF8; -.
DR   BRENDA; 6.3.4.16; 5242.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008804; F:carbamate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006525; P:arginine metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04235; AAK_CK; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR003964; Carb_kinase.
DR   InterPro; IPR023000; Shikimate_kinase_CS.
DR   PANTHER; PTHR30409; PTHR30409; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000723; Carbamate_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00746; arcC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN           1..314
FT                   /note="Carbamate kinase"
FT                   /id="PRO_0000185148"
SQ   SEQUENCE   314 AA;  34355 MW;  85DED48E6A01A8B2 CRC64;
     MPERVVIALG GNALQQRGQK GTYEEMMENV KKTAKQIAEI IARGYEVVIT HGNGPQVGTI
     LLHMDAGQSL HGIPAQPMDV AGAMSQGWIG YMIQQALRNE LRKRGIEREV VTIVTQTIVD
     KDDPAFENPT KPVGPFYDEE TAKKLAKEKG WVVKEDAGRG WRRVVPSPDP KRHVEAETIK
     KLVEDGVIVI ASGGGGVPVI EEDGEIKGVE AVIDKDLAGE RLAEEVNADI LMILTDVNGA
     ALYYGTEKET WLREVKVDEM ERYYQEGHFK AGSMGPKVLA AIRFVKNGGK RAIIAHLEKA
     VEALEGKTGT QVIP