ID   CPB2_CAEEL              Reviewed;         570 AA.
AC   Q18317;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 3.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Cytoplasmic polyadenylation element-binding protein 2;
GN   Name=cpb-2; ORFNames=C30B5.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION, FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=11040214; DOI=10.1101/gad.831700;
RA   Luitjens C., Gallegos M., Kraemer B., Kimble J., Wickens M.;
RT   "CPEB proteins control two key steps in spermatogenesis in C. elegans.";
RL   Genes Dev. 14:2596-2609(2000).
CC   -!- FUNCTION: Cytoplasmic polyadenylation element binding protein that
CC       binds to and regulates the translation of specific mRNAs (By
CC       similarity). Not required for oogenesis. {ECO:0000250,
CC       ECO:0000269|PubMed:11040214}.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in the spermatogenic germ
CC       line. {ECO:0000269|PubMed:11040214}.
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DR   EMBL; FO080719; CCD66139.1; -; Genomic_DNA.
DR   PIR; T15705; T15705.
DR   RefSeq; NP_495236.3; NM_062835.3.
DR   AlphaFoldDB; Q18317; -.
DR   SMR; Q18317; -.
DR   BioGRID; 39368; 2.
DR   IntAct; Q18317; 1.
DR   STRING; 6239.C30B5.3; -.
DR   PaxDb; Q18317; -.
DR   EnsemblMetazoa; C30B5.3.1; C30B5.3.1; WBGene00000771.
DR   EnsemblMetazoa; C30B5.3.2; C30B5.3.2; WBGene00000771.
DR   GeneID; 174027; -.
DR   KEGG; cel:CELE_C30B5.3; -.
DR   UCSC; C30B5.3; c. elegans.
DR   CTD; 174027; -.
DR   WormBase; C30B5.3; CE44953; WBGene00000771; cpb-2.
DR   eggNOG; KOG0129; Eukaryota.
DR   GeneTree; ENSGT00940000169843; -.
DR   HOGENOM; CLU_034584_0_0_1; -.
DR   InParanoid; Q18317; -.
DR   OMA; DWPSKHY; -.
DR   OrthoDB; 1075356at2759; -.
DR   PhylomeDB; Q18317; -.
DR   PRO; PR:Q18317; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00000771; Expressed in embryo and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0008135; F:translation factor activity, RNA binding; IBA:GO_Central.
DR   GO; GO:2000766; P:negative regulation of cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 4.10.640.40; -; 1.
DR   InterPro; IPR032296; CEBP_ZZ.
DR   InterPro; IPR038446; CEBP_ZZ_sf.
DR   InterPro; IPR034819; CPEB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR12566; PTHR12566; 1.
DR   Pfam; PF16366; CEBP_ZZ; 1.
DR   Pfam; PF16367; RRM_7; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..570
FT                   /note="Cytoplasmic polyadenylation element-binding protein
FT                   2"
FT                   /id="PRO_0000081513"
FT   DOMAIN          434..516
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   570 AA;  66002 MW;  13E3DB81D02D5362 CRC64;
     MSKSRRVFLS MQGDDDFWGN GDRFEEHKLS KMNRRKCRGM MDTAKDDVLD EHFFKQNNLV
     TQELEQQNAK SNDMFRERQD WNSSTPLEKI NLVESEDPVT CPENTEAKIH CSEVKVTEKM
     PLELDDEFYN NFREYFSSRP EVIFLTRSMH KDAAENYDKQ FIDLYEKTRK RLELRSSPQI
     NQILRCTSNT NATSSEIQLR NRQAVIVSNF REPDRRLGRY SKYYYHHNVG PEVYSRKVFV
     GGLPSCVKES DILNFFSRYG RLQVDWPSKH YECKSDSDPS LCNEPISSSS YQPSSHLAMV
     SPPFGEINPF MRNMPAQSES SQTGGFGRIS SGSIGGFLNP GMAQVARGNL GFGSTKSDGS
     INGDKRQHHL GYVFLLFEKE RSVRDLVLDC FEEEEGLFIT LESSTDSIRV QIRPWLLADA
     EFLMDFNVPI NTKLVAFIGG VPRPLKAVEL AHFFEQTYGH VVCVGIDIDN KFKYPRGSGR
     VAFSDYDAYV QAITDRYIVL DHEDIHKRVE IKPYFFHNQS CEECSGRYHR QHAPYFCPSL
     ECFQYYCEPC WHKMHSHPSR FHHMPVVKGV