COX2_THETH
ID COX2_THETH Reviewed; 135 AA.
AC P98052;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Cytochrome c oxidase subunit 2;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome c ba(3) subunit II;
DE AltName: Full=Cytochrome c oxidase polypeptide II;
DE AltName: Full=Cytochrome cba3 subunit 2;
DE Flags: Fragment;
GN Name=cbaB; Synonyms=ctaC;
OS Thermus thermophilus.
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=274;
RN [1]
RP X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
RX PubMed=10360350; DOI=10.1038/9274;
RA Williams P.A., Blackburn N.J., Sanders D., Bellamy H., Stura E.A.,
RA Fee J.A., McRee D.E.;
RT "The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at
RT 1.6-A resolution.";
RL Nat. Struct. Biol. 6:509-516(1999).
CC -!- FUNCTION: Subunits I and II form the functional core of the enzyme
CC complex. Electrons originating in cytochrome c are transferred via heme
CC a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC {ECO:0000305}.
CC -!- CAUTION: The sequence shown here has been extracted from PDB entry
CC 2CUA. {ECO:0000305}.
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DR PDB; 1XME; X-ray; 2.30 A; B=1-135.
DR PDB; 2CUA; X-ray; 1.60 A; A/B=1-135.
DR PDB; 2FWL; NMR; -; B=1-135.
DR PDB; 2LLN; NMR; -; A=11-135.
DR PDB; 5U7N; X-ray; 2.30 A; A/B/C/D/E/F/G/H=1-135.
DR PDBsum; 1XME; -.
DR PDBsum; 2CUA; -.
DR PDBsum; 2FWL; -.
DR PDBsum; 2LLN; -.
DR PDBsum; 5U7N; -.
DR AlphaFoldDB; P98052; -.
DR BMRB; P98052; -.
DR SMR; P98052; -.
DR IntAct; P98052; 1.
DR DrugBank; DB02451; B-nonylglucoside.
DR EvolutionaryTrace; P98052; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR CDD; cd13913; ba3_CcO_II_C; 1.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR034214; Ba3_CcO_II_C.
DR InterPro; IPR002429; CcO_II-like_C.
DR InterPro; IPR001505; Copper_CuA.
DR InterPro; IPR008972; Cupredoxin.
DR Pfam; PF00116; COX2; 1.
DR SUPFAM; SSF49503; SSF49503; 1.
DR PROSITE; PS00078; COX2; 1.
DR PROSITE; PS50857; COX2_CUA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Copper; Electron transport; Membrane;
KW Metal-binding; Respiratory chain; Translocase; Transmembrane; Transport.
FT CHAIN <1..135
FT /note="Cytochrome c oxidase subunit 2"
FT /id="PRO_0000183721"
FT BINDING 81
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A"
FT BINDING 116
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A"
FT BINDING 120
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A"
FT BINDING 124
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A"
FT NON_TER 1
FT HELIX 3..5
FT /evidence="ECO:0007829|PDB:2FWL"
FT HELIX 7..11
FT /evidence="ECO:0007829|PDB:2FWL"
FT STRAND 15..19
FT /evidence="ECO:0007829|PDB:2LLN"
FT TURN 22..27
FT /evidence="ECO:0007829|PDB:2CUA"
FT TURN 30..32
FT /evidence="ECO:0007829|PDB:2CUA"
FT HELIX 34..36
FT /evidence="ECO:0007829|PDB:2CUA"
FT STRAND 38..42
FT /evidence="ECO:0007829|PDB:2CUA"
FT STRAND 45..53
FT /evidence="ECO:0007829|PDB:2CUA"
FT STRAND 56..65
FT /evidence="ECO:0007829|PDB:2CUA"
FT STRAND 68..79
FT /evidence="ECO:0007829|PDB:2CUA"
FT STRAND 81..85
FT /evidence="ECO:0007829|PDB:2CUA"
FT TURN 86..89
FT /evidence="ECO:0007829|PDB:2LLN"
FT STRAND 91..94
FT /evidence="ECO:0007829|PDB:2CUA"
FT STRAND 96..99
FT /evidence="ECO:0007829|PDB:2LLN"
FT STRAND 100..105
FT /evidence="ECO:0007829|PDB:2CUA"
FT STRAND 110..115
FT /evidence="ECO:0007829|PDB:2CUA"
FT HELIX 124..126
FT /evidence="ECO:0007829|PDB:2FWL"
FT STRAND 128..134
FT /evidence="ECO:0007829|PDB:2CUA"
SQ SEQUENCE 135 AA; 14804 MW; 786895A803A52FAB CRC64;
AYTLATHTAG VIPAGKLERV DPTTVRQEGP WADPAQAVVQ TGPNQYTVYV LAFAFGYQPN
PIEVPQGAEI VFKITSPDVI HGFHVEGTNI NVEVLPGEVS TVRYTFKRPG EYRIICNQYC
GLGHQNMFGT IVVKE
