COPG_DROPS
ID COPG_DROPS Reviewed; 878 AA.
AC Q29AE5;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Coatomer subunit gamma {ECO:0000250|UniProtKB:Q8I0G5};
DE AltName: Full=Gamma-coat protein {ECO:0000250|UniProtKB:Q8I0G5};
DE Short=Gamma-COP {ECO:0000250|UniProtKB:Q8I0G5};
GN Name=gammaCop {ECO:0000250|UniProtKB:Q8I0G5}; ORFNames=GA13624;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL27405.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC Required for limiting lipid storage in lipid droplets. Involved in the
CC expansion of luminal extracellular matrices and apical membrane during
CC tubulogenesis. Required in the tracheal epithelium for luminal protein
CC secretion and diametric tube growth. In salivary glands, required for
CC deposition of O-glycans and luminal extracellular matrix assembly.
CC Required for epidermal morphogenesis and cuticle development (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000250|UniProtKB:P32074, ECO:0000250|UniProtKB:P53622}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P32074,
CC ECO:0000250|UniProtKB:P53622, ECO:0000250|UniProtKB:Q8I0G5}. Golgi
CC apparatus membrane {ECO:0000250|UniProtKB:P32074,
CC ECO:0000250|UniProtKB:P53622, ECO:0000250|UniProtKB:Q8I0G5}; Peripheral
CC membrane protein {ECO:0000250|UniProtKB:P32074,
CC ECO:0000250|UniProtKB:P53622, ECO:0000250|UniProtKB:Q8I0G5};
CC Cytoplasmic side {ECO:0000250|UniProtKB:P32074,
CC ECO:0000250|UniProtKB:P53622, ECO:0000250|UniProtKB:Q8I0G5}.
CC Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000250|UniProtKB:P32074, ECO:0000250|UniProtKB:P53622,
CC ECO:0000250|UniProtKB:Q8I0G5}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P32074, ECO:0000250|UniProtKB:P53622,
CC ECO:0000250|UniProtKB:Q8I0G5}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P32074, ECO:0000250|UniProtKB:P53622,
CC ECO:0000250|UniProtKB:Q8I0G5}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:P32074, ECO:0000250|UniProtKB:P53622,
CC ECO:0000250|UniProtKB:Q8I0G5}. Note=The coatomer is cytoplasmic or
CC polymerized on the cytoplasmic side of the Golgi, as well as on the
CC vesicles/buds originating from it. {ECO:0000250|UniProtKB:P32074,
CC ECO:0000250|UniProtKB:P53622, ECO:0000250|UniProtKB:Q8I0G5}.
CC -!- SIMILARITY: Belongs to the COPG family. {ECO:0000255}.
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DR EMBL; CM000070; EAL27405.1; -; Genomic_DNA.
DR AlphaFoldDB; Q29AE5; -.
DR SMR; Q29AE5; -.
DR STRING; 7237.FBpp0282417; -.
DR eggNOG; KOG1078; Eukaryota.
DR HOGENOM; CLU_010353_2_0_1; -.
DR InParanoid; Q29AE5; -.
DR OMA; YMTQYHA; -.
DR PhylomeDB; Q29AE5; -.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 2.
DR Gene3D; 2.60.40.1480; -; 1.
DR Gene3D; 3.30.310.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR032154; Coatomer_g_Cpla.
DR InterPro; IPR017106; Coatomer_gsu.
DR InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR InterPro; IPR037067; Coatomer_gsu_app_sf.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10261; PTHR10261; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF16381; Coatomer_g_Cpla; 1.
DR Pfam; PF08752; COP-gamma_platf; 1.
DR PIRSF; PIRSF037093; Coatomer_gamma_subunit; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF49348; SSF49348; 1.
DR SUPFAM; SSF55711; SSF55711; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..878
FT /note="Coatomer subunit gamma"
FT /id="PRO_0000405328"
FT REPEAT 64..101
FT /note="HEAT 1"
FT REPEAT 287..324
FT /note="HEAT 2"
FT REPEAT 326..359
FT /note="HEAT 3"
FT REPEAT 360..396
FT /note="HEAT 4"
FT REPEAT 399..434
FT /note="HEAT 5"
FT REPEAT 471..508
FT /note="HEAT 6"
SQ SEQUENCE 878 AA; 97357 MW; B25C075F7AEBECC0 CRC64;
MGSFRRDKEE EDDGPTNAYQ NLEKTSVLQE TRTFNETPVN ARKCIHILTK ILYLINQGET
LVPREATDCF FAMTKLFQSK DVVLRRMVYL GIKELSSVAE DVIIVTSSLT KDMTGKEDLY
RAAAIRALCS ITDHTMLQAV ERYMKQCIVD KNAAVSCAAL VSSLRLATTA GDVVKRWANE
AQEAMNSDNI MVQYHALGLL YHIRKSDRLA VSKLVNKLTR SSLKSPYAVC MLIRIACKLI
EEEDIPSEEL SDSPLFTFIE TCLRHKSEMV IYEAAHAIVN LKNTNHRMLS PAFSILQLFC
SSPKATLRFA AVRTLNKVAM THPAAVTTCN LDLEGLITDS NRSVATLAIT TLLKTGAESS
VERLMKQIST FVAEISDEFK IVVVQAICAL CTKYPRKHTV LMNFLSGMLR EEGGLEYKTS
IVDTIITIIE ENADAKESGL SHLCEFIEDC EHVSLAVRIL HLMGKEGPFA ATPSKYIRFI
YNRVILESPI VRAAAVTALS QFGASCPALL TNILVLLGRC QMDPDDEVRD RATYYLTILN
TERADLYKNY IIERENCSLA LLEKALVDHL NGDLEKRFDI SVVPKAAAVV RAEISNDVML
VTSAPRPPKI TREEESASRL AQLPGIQVLG PVHRSTAPIQ LTESETEYTV QCIKHIFGQH
VVFQFDCLNT LSDQFLENVR VELTLPEGFT TRAVVPCPKL PYNELQTTYV IVEFPPDAGS
SIATFGATLR FVVKDCDPNT GEPDSEEGYD DEYMLEDMEI TVADQIQKSK KNNFQVAWDA
ADSEEWLQAE DTFVLSAVTT LQDAVNTIMK ILGLGSANLS EKVPEGTHLH TLLCSGTFRG
GAEVLVRAKL ALSEGVTLNL TVRSTDQDVA ELITAAIG
