COPG_DICDI
ID COPG_DICDI Reviewed; 898 AA.
AC Q54HL0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Coatomer subunit gamma;
DE AltName: Full=Gamma-coat protein;
DE Short=Gamma-COP;
GN Name=copG; ORFNames=DDB_G0289371;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on
CC the cytoplasmic side of the Golgi, as well as on the vesicles/buds
CC originating from it. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COPG family. {ECO:0000305}.
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DR EMBL; AAFI02000139; EAL62772.1; -; Genomic_DNA.
DR RefSeq; XP_636291.1; XM_631199.1.
DR AlphaFoldDB; Q54HL0; -.
DR SMR; Q54HL0; -.
DR IntAct; Q54HL0; 1.
DR STRING; 44689.DDB0233801; -.
DR PaxDb; Q54HL0; -.
DR PRIDE; Q54HL0; -.
DR EnsemblProtists; EAL62772; EAL62772; DDB_G0289371.
DR GeneID; 8627109; -.
DR KEGG; ddi:DDB_G0289371; -.
DR dictyBase; DDB_G0289371; copG.
DR eggNOG; KOG1078; Eukaryota.
DR HOGENOM; CLU_010353_2_0_1; -.
DR InParanoid; Q54HL0; -.
DR OMA; YMTQYHA; -.
DR PhylomeDB; Q54HL0; -.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DDI-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:Q54HL0; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0030126; C:COPI vesicle coat; ISS:dictyBase.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.1480; -; 1.
DR Gene3D; 3.30.310.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR032154; Coatomer_g_Cpla.
DR InterPro; IPR017106; Coatomer_gsu.
DR InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR InterPro; IPR037067; Coatomer_gsu_app_sf.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10261; PTHR10261; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF16381; Coatomer_g_Cpla; 1.
DR Pfam; PF08752; COP-gamma_platf; 1.
DR PIRSF; PIRSF037093; Coatomer_gamma_subunit; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF49348; SSF49348; 1.
DR SUPFAM; SSF55711; SSF55711; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Repeat; Transport.
FT CHAIN 1..898
FT /note="Coatomer subunit gamma"
FT /id="PRO_0000327839"
FT REPEAT 62..99
FT /note="HEAT 1"
FT REPEAT 170..207
FT /note="HEAT 2"
FT REPEAT 280..317
FT /note="HEAT 3"
FT REPEAT 319..352
FT /note="HEAT 4"
FT REPEAT 353..389
FT /note="HEAT 5"
FT REPEAT 392..427
FT /note="HEAT 6"
FT REGION 592..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 101509 MW; 46FDED589F087C3F CRC64;
MASRVQKKDD DESDFLFENL DKGQVIQEKR AFNESPIHPR KCSLVISQFL YLLSRGDSFT
KTEATDIFFA ATKLFQSKDI PLRRLMYLLL KELSTISQDA IIVISSLTKD MSHKIELYRA
NAIRILCKIT DSSILPQIER YFKQSIVEKD PHVSSAALVS SIHLLKVCPE IVKRWANEVQ
EAISNKSNMV QYHALALLHR IKQHDRLAVS KLVSNLIKNS LRSPYAQSYL IRCCVEVIEE
TNTEDRIFRE YIESCLRSKN EMVAYEAARS ICTFKNVSNK EINSAVGVLQ NFLNSTKPTL
RFAAVRTLNK LAQTNPTAVI PCNLDMENLI TDTNRSIATL AITTLLKVGN ESNVERLIKQ
IANFLGDIND EFKIVVVDAI TSLSQKFPKK YKHLIIFLNK ILRDEGTLQL KQATLDAILT
VVNNIPESKE IALTELCDYI EDCDFPDLSV QILHLIGQEG PLTSSPAQYM RYIYNRVLLD
GGIIRAAAVT SIAKFGLLYE PMKEKVVILL QRCLLDEDDE VRDRATLYLK LFKENDVRYL
NKVLMDDVPV PLNNLQKSLE LYLHQGDFSE PFDIASVSTV VETYQSPLLG DGKSPFSTGA
SKKGDSVTGT PKSNNASNNN NNNEESSGPE SFATKLSQIP QFSTFGKLLK SSEYIELTET
ETEYVVNCVK HIYREHIVFQ FNCTNTLNEQ QLSNVSVKMV PSDPKLLKYE CSIPIDVLPY
GEPQQCYVAI RYIPANGYPL CSFSNALKFK VKEVDPSTGE LDEPGYDDQY SLERLEIVPK
DFLNRAFVGN FSEEWKKMSE DTQLVQTFSL VGVKSIDEAV KQIIKTLGMA PAEKSEVVTP
KSAKHILYLT GKSLNNQLIY VRARMKLDQS QTNTDVELTI KSDDESLNDF VISAFIEK
