COPG_CAEEL
ID COPG_CAEEL Reviewed; 870 AA.
AC Q22498;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Probable coatomer subunit gamma;
DE AltName: Full=Gamma-coat protein;
DE Short=Gamma-COP;
GN Name=copg-1 {ECO:0000312|WormBase:T14G10.5a};
GN ORFNames=T14G10.5 {ECO:0000312|WormBase:T14G10.5a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on
CC the cytoplasmic side of the Golgi, as well as on the vesicles/buds
CC originating from it. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COPG family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284604; CAA93095.1; -; Genomic_DNA.
DR PIR; T24915; T24915.
DR RefSeq; NP_001040988.1; NM_001047523.2.
DR AlphaFoldDB; Q22498; -.
DR SMR; Q22498; -.
DR BioGRID; 42993; 2.
DR STRING; 6239.T14G10.5c; -.
DR EPD; Q22498; -.
DR PaxDb; Q22498; -.
DR PeptideAtlas; Q22498; -.
DR EnsemblMetazoa; T14G10.5a.1; T14G10.5a.1; WBGene00011775.
DR EnsemblMetazoa; T14G10.5a.2; T14G10.5a.2; WBGene00011775.
DR GeneID; 177891; -.
DR UCSC; T14G10.5b; c. elegans.
DR CTD; 177891; -.
DR WormBase; T14G10.5a; CE06451; WBGene00011775; copg-1.
DR eggNOG; KOG1078; Eukaryota.
DR HOGENOM; CLU_010353_2_0_1; -.
DR InParanoid; Q22498; -.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:Q22498; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00011775; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q22498; baseline and differential.
DR GO; GO:0030126; C:COPI vesicle coat; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0072384; P:organelle transport along microtubule; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR Gene3D; 2.60.40.1480; -; 1.
DR Gene3D; 3.30.310.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR032154; Coatomer_g_Cpla.
DR InterPro; IPR017106; Coatomer_gsu.
DR InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR InterPro; IPR037067; Coatomer_gsu_app_sf.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR10261; PTHR10261; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF16381; Coatomer_g_Cpla; 1.
DR Pfam; PF08752; COP-gamma_platf; 1.
DR PIRSF; PIRSF037093; Coatomer_gamma_subunit; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF49348; SSF49348; 1.
DR SUPFAM; SSF55711; SSF55711; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Repeat; Transport.
FT CHAIN 1..870
FT /note="Probable coatomer subunit gamma"
FT /id="PRO_0000193859"
FT REPEAT 60..97
FT /note="HEAT 1"
FT REPEAT 99..133
FT /note="HEAT 2"
FT REPEAT 168..205
FT /note="HEAT 3"
FT REPEAT 278..315
FT /note="HEAT 4"
FT REPEAT 316..350
FT /note="HEAT 5"
FT REPEAT 389..425
FT /note="HEAT 6"
SQ SEQUENCE 870 AA; 96302 MW; 24CCA86160A60049 CRC64;
MKTNKKDEET GGNVYAHLDK TSVLQEARAF NETPINARKC CFILSKLIYI IQQGESIGRT
EATEAFFGVT KLWQSKDVSL RRMVYLAVKE LAEVSDDVII VTSSLTKDMT GREDLYRAAA
IRALCKITDT GMLQTIERYM KQAIVDRNSA ISSSAIVSSI HLMRKSSEVV RRWANEVQEA
VSSDNHMVQY HALALLYQIR ANDRLAVNKL VQKFSKNALR SPYAVCYLIR IATRCLVDDD
QPDSSVFTFI ESCLRHKSEM VVYEAARAIV SLPQTTPSEI QPAITALQMC CTSPKAAVRF
AAVRTLNKVA MAHPNAVMSC NVDLEKFITD PNRSIATLAI TTLLKTGAES SVERLMQQIA
GFVNEISDEF KIVVVDAIRS LCSRYPRKHT VMMPFLAKML RSDGSYDYKK AIVETIIAII
EENPDAKVAG LAHLCEFIED CEHDNLSTRV LHLLGREAPK TPNPSSYIRF IYNRVILEST
KVRAAAVTAL AKFGAQCVDL RPSIQVLLKR CLLDSDDEVR DRATFYLKML TEAAEGLIHN
FILDGLQVSP SGLERSILDY LRSGSYSSPF DLRVVPVTQQ ALSQPEKRVP QLVEEEEKPK
APKVEPYAAQ LAAIPQFAAL GPVFKSSTRI ALTESIAEYT VHMIKHTFAN AMVLQFECKN
TMNDQLLLDV SVELEDPDGE WETGNTVQID KLPYGEVHSA FSLLEFPDSG AISGSLGAIL
KFKVMDVDPT SGEPDSDDTY EQTYVLEEVD VNVSDSVQGV AKSSFGSAWE ALGDDATREE
TFQLSTVENI PDAVKKISEI LGLVPCERSD RVPEGKTQHT VFLSGVFRGG YDVLSKATVA
VDPNDNSIAM NIIIKSNEPL VADLVISAVV
