ID   COPG2_XENTR             Reviewed;         872 AA.
AC   Q66JI9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Coatomer subunit gamma-2;
DE   AltName: Full=Gamma-2-coat protein;
DE            Short=Gamma-2-COP;
GN   Name=copg2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC       dilysine motifs and reversibly associates with Golgi non-clathrin-
CC       coated vesicles, which further mediate biosynthetic protein transport
CC       from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC       complex is required for budding from Golgi membranes, and is essential
CC       for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Oligomeric complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COPG family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC080897; AAH80897.1; -; mRNA.
DR   RefSeq; NP_001008019.1; NM_001008018.1.
DR   AlphaFoldDB; Q66JI9; -.
DR   SMR; Q66JI9; -.
DR   STRING; 8364.ENSXETP00000035553; -.
DR   PaxDb; Q66JI9; -.
DR   DNASU; 493381; -.
DR   GeneID; 493381; -.
DR   KEGG; xtr:493381; -.
DR   CTD; 26958; -.
DR   Xenbase; XB-GENE-941264; copg2.
DR   eggNOG; KOG1078; Eukaryota.
DR   InParanoid; Q66JI9; -.
DR   OrthoDB; 255234at2759; -.
DR   Reactome; R-XTR-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-XTR-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0030126; C:COPI vesicle coat; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0072384; P:organelle transport along microtubule; IBA:GO_Central.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   Gene3D; 2.60.40.1480; -; 1.
DR   Gene3D; 3.30.310.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR032154; Coatomer_g_Cpla.
DR   InterPro; IPR017106; Coatomer_gsu.
DR   InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR   InterPro; IPR037067; Coatomer_gsu_app_sf.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10261; PTHR10261; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF16381; Coatomer_g_Cpla; 1.
DR   Pfam; PF08752; COP-gamma_platf; 1.
DR   PIRSF; PIRSF037093; Coatomer_gamma_subunit; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49348; SSF49348; 1.
DR   SUPFAM; SSF55711; SSF55711; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Repeat; Transport.
FT   CHAIN           1..872
FT                   /note="Coatomer subunit gamma-2"
FT                   /id="PRO_0000342522"
FT   REPEAT          64..101
FT                   /note="HEAT 1"
FT   REPEAT          283..320
FT                   /note="HEAT 2"
FT   REPEAT          321..355
FT                   /note="HEAT 3"
FT   REPEAT          356..392
FT                   /note="HEAT 4"
FT   REPEAT          395..430
FT                   /note="HEAT 5"
FT   REPEAT          467..504
FT                   /note="HEAT 6"
SQ   SEQUENCE   872 AA;  97936 MW;  1873F3C0EDD3E732 CRC64;
     MIKKFDKKDE ESGIGSNPFQ HLEKSAVLQE ARLFNETPIN PRRCLHILTK ILYLLNQGEH
     FGTMEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMANISE DVIIVTSSLT KDMTGKEDVY
     RGPAIRALCR ITDATMLQGI ERYMKQAIVD KVSSVSSSAL VSSLHMTKIS YDVVKRWINE
     AQEAASSDNI MVQYHALGLL YNLRKNDRLA VSKMLNKFTK SGLKSPFAYC MLIRIASRLL
     EESEEGHNSP LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK
     PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK TGSESSVDRL
     MKQISTFVSE ISDEFKVVVV QAISALCQKY PRKHSVMMTF LSNMLRDDGG FEYKRAIVDC
     IISIIEENPD SKESGLAHLC EFIEDCEHTV LATKILHLLG REGPKTPTPS KYIRFIFNRV
     VLENEAVRAA AVSALAKFGA QNEPLLPSVL VLLQRCMMDS DDEVRDRATF YFNVLNQNQL
     ALNTAYIFNG LTVSVFGMEK ALHQYTLEPS EKPFDMKTVP LATVPFLEQK TDLAPIATKQ
     PEKMVPVRQD IFQDQLAAIP EFKNLGPLFK SSEPVQLTEA ETEYFVRCIK HVFPNHIVFQ
     FDCTNTLNDQ LLEKVTVQME PSEAYEVVHY VPAPSLPYNQ PGISYTLVRL PDDDPTAVSC
     TFSCTMKFVV RDCDPQTGVP DDEGYSDEYV LEDLEVTLSD HIQKILKPNF GAAWEEIGDT
     YEKEETFALT TTKSLEEAVN NIIKFLGMQP CERSDKVPEN KNSHVLYLSG VYRGGHDVLV
     RSRLALADGV TMQVTVRSQD ETPANVILVS VG