ID   COPG2_XENLA             Reviewed;         872 AA.
AC   Q6DKD7;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Coatomer subunit gamma-2;
DE   AltName: Full=Gamma-2-coat protein;
DE            Short=Gamma-2-COP;
GN   Name=copg2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC       dilysine motifs and reversibly associates with Golgi non-clathrin-
CC       coated vesicles, which further mediate biosynthetic protein transport
CC       from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC       complex is required for budding from Golgi membranes, and is essential
CC       for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Oligomeric complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COPG family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC074209; AAH74209.1; -; mRNA.
DR   RefSeq; NP_001086117.1; NM_001092648.1.
DR   AlphaFoldDB; Q6DKD7; -.
DR   SMR; Q6DKD7; -.
DR   BioGRID; 102709; 2.
DR   IntAct; Q6DKD7; 1.
DR   DNASU; 444546; -.
DR   GeneID; 444546; -.
DR   KEGG; xla:444546; -.
DR   CTD; 444546; -.
DR   Xenbase; XB-GENE-941269; copg2.S.
DR   OrthoDB; 255234at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 444546; Expressed in testis and 19 other tissues.
DR   GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 2.
DR   Gene3D; 2.60.40.1480; -; 1.
DR   Gene3D; 3.30.310.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR032154; Coatomer_g_Cpla.
DR   InterPro; IPR017106; Coatomer_gsu.
DR   InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR   InterPro; IPR037067; Coatomer_gsu_app_sf.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10261; PTHR10261; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF16381; Coatomer_g_Cpla; 1.
DR   Pfam; PF08752; COP-gamma_platf; 1.
DR   PIRSF; PIRSF037093; Coatomer_gamma_subunit; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49348; SSF49348; 1.
DR   SUPFAM; SSF55711; SSF55711; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Repeat; Transport.
FT   CHAIN           1..872
FT                   /note="Coatomer subunit gamma-2"
FT                   /id="PRO_0000342521"
FT   REPEAT          64..101
FT                   /note="HEAT 1"
FT   REPEAT          283..320
FT                   /note="HEAT 2"
FT   REPEAT          321..355
FT                   /note="HEAT 3"
FT   REPEAT          356..392
FT                   /note="HEAT 4"
FT   REPEAT          395..430
FT                   /note="HEAT 5"
FT   REPEAT          467..504
FT                   /note="HEAT 6"
SQ   SEQUENCE   872 AA;  97792 MW;  239C24E6973F784A CRC64;
     MIKKFDKKDE ESGIGSNPFQ HLEKSAVLQE ARLFNETPIN PRRCLHILTK ILYLLNQGEH
     FGTMEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMANISE DVIIVTSSLT KDMTGKEDVY
     RGPAIRALCR ITDATMLQGI ERYMKQAIVD KIPSVSSSAL VSSLNMTKIS YDVVKRWINE
     AQEAASSDNI MVQYHALGLL YNLKKNDRLA VSKMLNKYTK SGVKSPFAYC MLIRIASRLL
     EESEEGHNSP LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK
     PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK TGSESSVDRL
     MKQISTFVSE ISDEFKVVVV QAISALCQKY PRKHSVMMTF LSNMLRDDGG FEYKRAIVDC
     IISIIEENPD SKESGLAHMC EFIEDCEHTV LATKILHLLG KEGPKTPTPS KYIRFIFNRV
     VLENEAVRAA AVSALAKFGA QNESLLPSVL VLLQRCMMDS DDEVRDRATF YFNVLKQQQL
     ALNAAYIFNG LTVSVFGMEK ALHQYTLEPS EKPFDMKTVP LATVPFMDQK TDLAPMATKQ
     PEKAVPVRQD IFQEQLAVIP EFKNLGPLFK SSEPVQLTEA ETEYFVRCIK HVFPNHFVFQ
     FDCTNTLNDQ LLEKVTVQME PSEAYEVLHY VPAPSLTYNQ PGICYTLVSL PDDDPTAVSC
     TFSCTMKFVV RDCDPQTGVP DDEGYSDEYV LEDLELSLSD HIQKVLKPNF GASWEEVGDA
     YEKEETFALT TTKTLEEAVN NIIKFLGMQP CERSDKVPEN KNSHVLYLSG VFRGGHDALV
     RSRLALADGV TMQVTVRSQD ETPADVILAS VG