ID   COPG2_TAKRU             Reviewed;         873 AA.
AC   Q9I8E6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Coatomer subunit gamma-2;
DE   AltName: Full=Gamma-2-coat protein;
DE            Short=Gamma-2-COP;
GN   Name=copg2;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11032317; DOI=10.1023/a:1009263504671;
RA   Brunner B., Gruetzner F., Yaspo M.-L., Ropers H.-H., Haaf T.,
RA   Kalscheuer V.M.;
RT   "Molecular cloning and characterization of the Fugu rubripes MEST/COPG2
RT   imprinting cluster and chromosomal localization in Fugu and Tetraodon
RT   nigroviridis.";
RL   Chromosome Res. 8:465-476(2000).
CC   -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC       dilysine motifs and reversibly associates with Golgi non-clathrin-
CC       coated vesicles, which further mediate biosynthetic protein transport
CC       from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC       complex is required for budding from Golgi membranes, and is essential
CC       for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Oligomeric complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COPG family. {ECO:0000305}.
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DR   EMBL; AJ251323; CAB96534.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9I8E6; -.
DR   SMR; Q9I8E6; -.
DR   STRING; 31033.ENSTRUP00000040385; -.
DR   eggNOG; KOG1078; Eukaryota.
DR   InParanoid; Q9I8E6; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 2.
DR   Gene3D; 2.60.40.1480; -; 1.
DR   Gene3D; 3.30.310.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR032154; Coatomer_g_Cpla.
DR   InterPro; IPR017106; Coatomer_gsu.
DR   InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR   InterPro; IPR037067; Coatomer_gsu_app_sf.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10261; PTHR10261; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF16381; Coatomer_g_Cpla; 1.
DR   Pfam; PF08752; COP-gamma_platf; 1.
DR   PIRSF; PIRSF037093; Coatomer_gamma_subunit; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49348; SSF49348; 1.
DR   SUPFAM; SSF55711; SSF55711; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Repeat; Transport.
FT   CHAIN           1..873
FT                   /note="Coatomer subunit gamma-2"
FT                   /id="PRO_0000342520"
FT   REPEAT          64..101
FT                   /note="HEAT 1"
FT   REPEAT          283..320
FT                   /note="HEAT 2"
FT   REPEAT          321..355
FT                   /note="HEAT 3"
FT   REPEAT          356..392
FT                   /note="HEAT 4"
FT   REPEAT          394..430
FT                   /note="HEAT 5"
FT   REPEAT          467..504
FT                   /note="HEAT 6"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   873 AA;  97470 MW;  31154D8BFF3AF440 CRC64;
     MIKKFDKKDE ESGSGSNPFQ NLEKSAVLQE ARIFNETPIN PRRCLHILTK IIYLLNQGEH
     FGTTEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMANISE DVIIVTSSLT KDMTGKEDVY
     RGPAIRALCR ITDTTMLQAI ERYMKQAIVD KVPSVSSSAL VSSLHMVKMS YDVVKRWVNE
     AQEAASSDNI MVQYHALGLL YHLRKNDRLA VTKMLNKFTK SGLKSPFAYC MLIRIASKLL
     DETEAGHDSP LFDFIESCLR NKNEMVVYEA ASAIVHMPNC TARELAPAVS VLQLFCSSPK
     AALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK TGSESSVDRL
     MKQISSFVSE ISDEFKVVVV QAISALCQKY PRKHSAMMNF LSNMLRDDGG FEYKRAIVDC
     IISIIEENPE SKETGLAHLC EFIEDCEHTV LATKILHLLG KEGPRTPQPS KYIRFIFNRV
     VLESEAVRAA AVSALAKFGA QNDDLLPSVL VLMQRCMMDS DDEVRDRATF YMNVLQQKQK
     ALNAAYIFNG LSVSIPGLEK SLHQYTLEPS EKPFDMKSVP LATTPITEQK TEIAPAATSK
     LPEKLAPSRQ DIYQEQLAAI PEFQGLGPLF KSSDPVQLTE AETEYVVRCI KHTFARHMVF
     QFDCTNTLND QLLQKVLVQM EPSEAYEVIH YIPAPSLPYS QPGSCYSLVR LPDDDPTAVS
     CTFSCTMKYL VRDCDPNTGE PDDDGYDDEY VLEDLEVTVP DHIQKVLKPN FGAAWEEVGD
     EFEKEETFAL ASVRTLDEAV GNIISFLGMQ PCERSDKVPE NKNSHVLFLA GVFRGGHDVL
     VRARLALADG VTMQVTVRSS EETVVDVILA SVG