ID   COPE_CHICK              Reviewed;         308 AA.
AC   Q5ZIK9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Coatomer subunit epsilon;
DE   AltName: Full=Epsilon-coat protein;
DE            Short=Epsilon-COP;
GN   Name=COPE; ORFNames=RCJMB04_25f12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC       dilysine motifs and reversibly associates with Golgi non-clathrin-
CC       coated vesicles, which further mediate biosynthetic protein transport
CC       from the ER, via the Golgi up to the trans Golgi network. The coatomer
CC       complex is required for budding from Golgi membranes, and is essential
CC       for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC       beta', gamma, delta, epsilon and zeta subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on
CC       the cytoplasmic side of the Golgi, as well as on the vesicles/buds
CC       originating from it. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COPE family. {ECO:0000305}.
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DR   EMBL; AJ720775; CAG32434.1; -; mRNA.
DR   RefSeq; NP_001006339.1; NM_001006339.1.
DR   AlphaFoldDB; Q5ZIK9; -.
DR   SMR; Q5ZIK9; -.
DR   BioGRID; 681127; 1.
DR   STRING; 9031.ENSGALP00000004982; -.
DR   PaxDb; Q5ZIK9; -.
DR   Ensembl; ENSGALT00000004991; ENSGALP00000004982; ENSGALG00000003153.
DR   GeneID; 420117; -.
DR   KEGG; gga:420117; -.
DR   CTD; 11316; -.
DR   VEuPathDB; HostDB:geneid_420117; -.
DR   eggNOG; KOG3081; Eukaryota.
DR   GeneTree; ENSGT00390000003478; -.
DR   HOGENOM; CLU_049363_0_0_1; -.
DR   InParanoid; Q5ZIK9; -.
DR   OMA; MIVLSQH; -.
DR   OrthoDB; 1161199at2759; -.
DR   PhylomeDB; Q5ZIK9; -.
DR   TreeFam; TF313390; -.
DR   Reactome; R-GGA-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-GGA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:Q5ZIK9; -.
DR   Proteomes; UP000000539; Chromosome 28.
DR   Bgee; ENSGALG00000003153; Expressed in colon and 14 other tissues.
DR   GO; GO:0030126; C:COPI vesicle coat; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR006822; Coatomer_esu.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR10805; PTHR10805; 1.
DR   PIRSF; PIRSF016478; Coatomer_esu; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..308
FT                   /note="Coatomer subunit epsilon"
FT                   /id="PRO_0000328666"
SQ   SEQUENCE   308 AA;  34369 MW;  F6B4F2FB90CD2A57 CRC64;
     MASGAGAGPA GQGGEADELF DVKNSFYIGA YQAAINEAQR IKPSNPEKET ERDVFLFRSY
     IAQRKYGVVL DEIKANASPE LQAVRMFAEY LSNESQRDAI VADLDKKMAK SVDVANTTFL
     LMAASIYFHD KNPDAALRTL HQGESLECMA MMIQILLKLD RLDLARKELK KMQEQDEDAT
     LTQLATAWVN LAIGGEKLQD AYYIFQEMAD KCSSTLLLLN GQAACYMAQG KWDDAEGVLQ
     EALDKDSGHP ETLINFVVLS QHLGKPPEVT NRYLSQLKDA HKNHPFIKEY QAKENDFDRL
     AMQYAPSA