ID   COPD_CHICK              Reviewed;         510 AA.
AC   Q5ZL57;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Coatomer subunit delta;
DE   AltName: Full=Archain;
DE   AltName: Full=Delta-coat protein;
DE            Short=Delta-COP;
GN   Name=ARCN1; Synonyms=COPD; ORFNames=RCJMB04_7j3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC       dilysine motifs and reversibly associates with Golgi non-clathrin-
CC       coated vesicles, which further mediate biosynthetic protein transport
CC       from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC       complex is required for budding from Golgi membranes, and is essential
CC       for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC       In mammals, the coatomer can only be recruited by membranes associated
CC       to ADP-ribosylation factors (ARFs), which are small GTP-binding
CC       proteins; the complex also influences the Golgi structural integrity,
CC       as well as the processing, activity, and endocytic recycling of LDL
CC       receptors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC       beta', gamma, delta, epsilon and zeta subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on
CC       the cytoplasmic side of the Golgi, as well as on the vesicles/buds
CC       originating from it. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC       Delta-COP subfamily. {ECO:0000305}.
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DR   EMBL; AJ719877; CAG31536.1; -; mRNA.
DR   RefSeq; NP_001072967.1; NM_001079499.1.
DR   AlphaFoldDB; Q5ZL57; -.
DR   SMR; Q5ZL57; -.
DR   BioGRID; 691278; 2.
DR   IntAct; Q5ZL57; 1.
DR   STRING; 9031.ENSGALP00000012007; -.
DR   PaxDb; Q5ZL57; -.
DR   Ensembl; ENSGALT00000012021; ENSGALP00000012007; ENSGALG00000007430.
DR   GeneID; 770561; -.
DR   KEGG; gga:770561; -.
DR   CTD; 372; -.
DR   VEuPathDB; HostDB:geneid_770561; -.
DR   eggNOG; KOG2635; Eukaryota.
DR   GeneTree; ENSGT00390000017207; -.
DR   HOGENOM; CLU_019988_3_0_1; -.
DR   InParanoid; Q5ZL57; -.
DR   OMA; YDARKHV; -.
DR   OrthoDB; 1027200at2759; -.
DR   PhylomeDB; Q5ZL57; -.
DR   TreeFam; TF105760; -.
DR   PRO; PR:Q5ZL57; -.
DR   Proteomes; UP000000539; Chromosome 24.
DR   Bgee; ENSGALG00000007430; Expressed in colon and 13 other tissues.
DR   ExpressionAtlas; Q5ZL57; baseline and differential.
DR   GO; GO:0030126; C:COPI vesicle coat; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0051645; P:Golgi localization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR027059; Coatomer_dsu.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR028565; MHD.
DR   PANTHER; PTHR10121; PTHR10121; 1.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   SUPFAM; SSF49447; SSF49447; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..510
FT                   /note="Coatomer subunit delta"
FT                   /id="PRO_0000193845"
FT   DOMAIN          270..510
FT                   /note="MHD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00404"
SQ   SEQUENCE   510 AA;  57170 MW;  5BD2C04CC5CE2C59 CRC64;
     MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TESVRYVYQP
     MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN EISEHCFDLI FAFDEIVALG
     YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERLGKKA
     PGFGGFGSSA VSGGTTAAMI TETIIETEKP KVAPAPSRPS GPSKALKLGA KGKEVDNFVD
     KLKSEGENIM TSVGKRSTEA AKVLAPPINM ESVHMKIEEK ISLTCGRDGG LQNMELHGMI
     MLHISDEKFA RIRLHVENED KRGVQLQTHP NVDKKLFTAE SQIGLKNPEK SFPINSDVGV
     LKWRLQTTEE SFIPLTINCW PSESGNSCDV NIEYELQEES LELNDVVIMI PLPSGVGAPV
     IGEIDGEYRH DSRRNLLEWC LPVIDAKNKS GSLEFSIAGQ PNDFFPVQVS FISKKNYCNI
     QVTKVTQVDG NSPVRFSTET TFLVDKYEIL