ID   COPB_PSEUB              Reviewed;         328 AA.
AC   P12375;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Copper resistance protein B;
DE   Flags: Precursor;
GN   Name=copB;
OS   Pseudomonas syringae pv. tomato.
OG   Plasmid pPT23D.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=323;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PT23.2;
RX   PubMed=3372485; DOI=10.1128/jb.170.6.2879-2883.1988;
RA   Mellano M.A., Cooksey D.A.;
RT   "Nucleotide sequence and organization of copper resistance genes from
RT   Pseudomonas syringae pv. tomato.";
RL   J. Bacteriol. 170:2879-2883(1988).
RN   [2]
RP   CHARACTERIZATION, AND PROTEIN SEQUENCE OF 28-32.
RC   STRAIN=PT23.2;
RX   PubMed=1924351; DOI=10.1073/pnas.88.20.8915;
RA   Cha J.-S., Cooksey D.A.;
RT   "Copper resistance in Pseudomonas syringae mediated by periplasmic and
RT   outer membrane proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:8915-8919(1991).
CC   -!- FUNCTION: Exact function not known. Possibly mediates copper resistance
CC       by its sequestration in the outer membrane.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- INDUCTION: By copper.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M19930; AAA25807.1; -; Genomic_DNA.
DR   PIR; B32018; B32018.
DR   RefSeq; WP_015062130.1; NZ_SNVE01000046.1.
DR   AlphaFoldDB; P12375; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IEA:InterPro.
DR   InterPro; IPR007939; Cu-R_B_prcur.
DR   Pfam; PF05275; CopB; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Copper; Direct protein sequencing; Membrane; Plasmid;
KW   Repeat; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000269|PubMed:1924351"
FT   CHAIN           28..328
FT                   /note="Copper resistance protein B"
FT                   /id="PRO_0000020981"
FT   REPEAT          36..43
FT                   /note="1"
FT   REPEAT          44..51
FT                   /note="2"
FT   REPEAT          52..59
FT                   /note="3"
FT   REPEAT          60..67
FT                   /note="4"
FT   REPEAT          68..75
FT                   /note="5"
FT   REGION          36..75
FT                   /note="5 X 8 AA tandem repeats of D-H-S-[QK]-M-Q-G-M"
FT   REGION          44..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   328 AA;  36248 MW;  D897C08C948E417A CRC64;
     MTVLNRLHVC SLLAVSSLGM LPVGVFAAEA AMPGVDHSQM QGMDHSKMQG MDHSQMQGMD
     HSKMQGMDHS QMQGMDSDMT TMAPSKPAAP TQSRTPIAPV TDANRAAVYR SAKGHTVHDE
     AANYFLLFDQ LEWQDADNGS VLNWDVNGWV GGDIDRLWIR SEGERTNGKT ESAELQALWG
     HAISPWWDLV GGVRQDFKPG SPQTWAAFGL QGLALYNFEA EATAFLGEGG QTGLRLEGDY
     DILLTNRLIL QPTAEVNFYG QSDPQRGIGS GLSETEVGVR LRYEIRREFA PYIGVTWNRS
     YGNTADFARE EGEDRSEARL VLGVRMWF