ID   COPB_ECO57              Reviewed;          84 AA.
AC   Q7BSX2; O82925;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Replication regulatory protein repA2;
DE   AltName: Full=Protein CopB;
GN   Name=repA2; Synonyms=copB; OrderedLocusNames=L7006, ECO57PM67;
OS   Escherichia coli O157:H7.
OG   Plasmid pO157.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=9722640; DOI=10.1093/nar/26.18.4196;
RA   Burland V., Shao Y., Perna N.T., Plunkett G. III, Sofia H.J.,
RA   Blattner F.R.;
RT   "The complete DNA sequence and analysis of the large virulence plasmid of
RT   Escherichia coli O157:H7.";
RL   Nucleic Acids Res. 26:4196-4204(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=9628576; DOI=10.1093/dnares/5.1.1;
RA   Makino K., Ishii K., Yasunaga T., Hattori M., Yokoyama K., Yatsudo H.C.,
RA   Kubota Y., Yamaichi Y., Iida T., Yamamoto K., Honda T., Han C.G.,
RA   Ohtsubo A., Kasamatsu M., Hayashi T., Kuhara S., Shinagawa H.;
RT   "Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an
RT   enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak.";
RL   DNA Res. 5:1-9(1998).
CC   -!- FUNCTION: This protein is involved in the determination of copy number
CC       in gene replication. It binds to the repA promoter thus inhibiting the
CC       synthesis of the mRNA for the initiator protein repA (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AF074613; AAC70074.1; -; Genomic_DNA.
DR   EMBL; AB011549; BAA31824.1; -; Genomic_DNA.
DR   PIR; T00305; T00305.
DR   RefSeq; NP_052674.1; NC_002128.1.
DR   RefSeq; WP_000083831.1; NZ_SWKA01000002.1.
DR   AlphaFoldDB; Q7BSX2; -.
DR   SMR; Q7BSX2; -.
DR   STRING; 155864.EDL933_p0006; -.
DR   EnsemblBacteria; AAC70074; AAC70074; Z_L7006.
DR   EnsemblBacteria; BAA31824; BAA31824; BAA31824.
DR   GeneID; 1789682; -.
DR   KEGG; ece:Z_L7006; -.
DR   KEGG; ecs:pO157p67; -.
DR   PATRIC; fig|386585.9.peg.78; -.
DR   eggNOG; ENOG50334KG; Bacteria.
DR   HOGENOM; CLU_180887_0_0_6; -.
DR   OMA; QLQEMCE; -.
DR   Proteomes; UP000000558; Plasmid pO157.
DR   Proteomes; UP000002519; Plasmid pO157.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006276; P:plasmid maintenance; IEA:UniProtKB-KW.
DR   InterPro; IPR019661; RepA2.
DR   Pfam; PF10723; RepB-RCR_reg; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Plasmid; Plasmid copy control; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..84
FT                   /note="Replication regulatory protein repA2"
FT                   /id="PRO_0000068293"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   84 AA;  9406 MW;  B993442D128E2C81 CRC64;
     MSQTENAVTS SSGAKRAYRK GNPLSDAEKQ RLSVARKRAS FKEVKVFLEP KYKAMLMQMC
     HEDGLTQAEV LTALIKSEAQ KRCV