ID   COPB3_ECOLX             Reviewed;          86 AA.
AC   P62536; P03855;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Replication regulatory protein repA2;
DE   AltName: Full=Protein CopB;
GN   Name=repA2; Synonyms=copB, repB;
OS   Escherichia coli.
OG   Plasmid IncFII R1-19 (R1 drd-19).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6261081; DOI=10.1007/bf00339014;
RA   Stougaard P., Molin S., Nordstroem K., Hansen F.G.;
RT   "The nucleotide sequence of the replication control region of the
RT   resistance plasmid R1drd-19.";
RL   Mol. Gen. Genet. 181:116-122(1981).
CC   -!- FUNCTION: This protein is involved in the determination of copy number
CC       in gene replication. It binds to the repA promoter thus inhibiting the
CC       synthesis of the mRNA for the initiator protein RepA.
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DR   PIR; A04484; WMEC5R.
DR   PIR; S11883; S11883.
DR   RefSeq; WP_000083819.1; NZ_WWEV01000027.1.
DR   RefSeq; YP_003829166.1; NC_014384.1.
DR   RefSeq; YP_003829326.1; NC_014385.1.
DR   RefSeq; YP_008997919.1; NC_023315.1.
DR   RefSeq; YP_443948.1; NC_007675.1.
DR   RefSeq; YP_788101.1; NC_008460.1.
DR   AlphaFoldDB; P62536; -.
DR   SMR; P62536; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006276; P:plasmid maintenance; IEA:UniProtKB-KW.
DR   InterPro; IPR019661; RepA2.
DR   Pfam; PF10723; RepB-RCR_reg; 1.
PE   4: Predicted;
KW   DNA-binding; Plasmid; Plasmid copy control; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..86
FT                   /note="Replication regulatory protein repA2"
FT                   /id="PRO_0000068292"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   86 AA;  10038 MW;  F7AD85B2C211CBF8 CRC64;
     MSQTENAVTS SLSQKRFVRR GKPMTDSEKQ MAAVARKRLT HKEIKVFVKN PLKDLMVEYC
     EREGITQAQF VEKIIKDELQ RLDILK