ID   COMB_BACSU              Reviewed;         228 AA.
AC   O06738;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Probable 2-phosphosulfolactate phosphatase;
DE            EC=3.1.3.71;
GN   Name=comB; Synonyms=yitC; OrderedLocusNames=BSU10940;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9353932; DOI=10.1099/00221287-143-10-3309;
RA   Roche B., Autret S., Levine A., Vannier F., Medina N., Seror S.J.;
RT   "A Bacillus subtilis chromosome segment at the 100 degrees to 102 degrees
RT   position encoding 11 membrane proteins.";
RL   Microbiology 143:3309-3312(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate +
CC         phosphate; Xref=Rhea:RHEA:23416, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15597, ChEBI:CHEBI:43474, ChEBI:CHEBI:58738; EC=3.1.3.71;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the ComB family. {ECO:0000305}.
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DR   EMBL; Y09476; CAA70658.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12934.1; -; Genomic_DNA.
DR   PIR; D69839; D69839.
DR   RefSeq; NP_388975.1; NC_000964.3.
DR   RefSeq; WP_003233050.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O06738; -.
DR   SMR; O06738; -.
DR   STRING; 224308.BSU10940; -.
DR   PaxDb; O06738; -.
DR   PRIDE; O06738; -.
DR   EnsemblBacteria; CAB12934; CAB12934; BSU_10940.
DR   GeneID; 936357; -.
DR   KEGG; bsu:BSU10940; -.
DR   PATRIC; fig|224308.179.peg.1176; -.
DR   eggNOG; COG2045; Bacteria.
DR   InParanoid; O06738; -.
DR   OMA; CAQYIAR; -.
DR   BioCyc; BSUB:BSU10940-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0050532; F:2-phosphosulfolactate phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0050545; F:sulfopyruvate decarboxylase activity; IBA:GO_Central.
DR   Gene3D; 3.90.1560.10; -; 1.
DR   HAMAP; MF_00490; ComB; 1.
DR   InterPro; IPR005238; ComB-like.
DR   InterPro; IPR036702; ComB-like_sf.
DR   PANTHER; PTHR37311; PTHR37311; 1.
DR   Pfam; PF04029; 2-ph_phosp; 1.
DR   SUPFAM; SSF142823; SSF142823; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Reference proteome.
FT   CHAIN           1..228
FT                   /note="Probable 2-phosphosulfolactate phosphatase"
FT                   /id="PRO_0000081464"
SQ   SEQUENCE   228 AA;  24661 MW;  3D705EC57170BD4E CRC64;
     MPIAIYQGHH HSLAPADINI VIDVIRAFTV AHYAFIGGAK EILLVRTADE AFALKDTYPD
     YVLTGEEKGV GISGFDLDNS PKRMAGQNMT DKSLIQKTTN GVTAALGALN AKHLFVTGFS
     NAKTTAQHVK KLVANDCVIN IVASHPSGDD DMACAEYIKG IIEGTNVVTA AEAIERIKGS
     SVAEKFFDCR QPLFDSEDIV YCTKELTGDF VMKVKQDGEV PTIERVII