COG3_MOUSE
ID COG3_MOUSE Reviewed; 820 AA.
AC Q8CI04;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 3;
DE Short=COG complex subunit 3;
DE AltName: Full=Component of oligomeric Golgi complex 3;
GN Name=Cog3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in ER-Golgi transport. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. Interacts with TMEM115. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC Note=Associated with the peripheral membrane of cis/medial cisternae.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG3 family. {ECO:0000305}.
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DR EMBL; BC038030; AAH38030.1; -; mRNA.
DR AlphaFoldDB; Q8CI04; -.
DR SMR; Q8CI04; -.
DR STRING; 10090.ENSMUSP00000045016; -.
DR iPTMnet; Q8CI04; -.
DR PhosphoSitePlus; Q8CI04; -.
DR EPD; Q8CI04; -.
DR MaxQB; Q8CI04; -.
DR PaxDb; Q8CI04; -.
DR PeptideAtlas; Q8CI04; -.
DR PRIDE; Q8CI04; -.
DR ProteomicsDB; 283343; -.
DR MGI; MGI:2450151; Cog3.
DR eggNOG; KOG2604; Eukaryota.
DR InParanoid; Q8CI04; -.
DR PhylomeDB; Q8CI04; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR ChiTaRS; Cog3; mouse.
DR PRO; PR:Q8CI04; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8CI04; protein.
DR GO; GO:0005801; C:cis-Golgi network; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0070085; P:glycosylation; ISO:MGI.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; ISO:MGI.
DR GO; GO:0033365; P:protein localization to organelle; ISO:MGI.
DR GO; GO:0050821; P:protein stabilization; ISO:MGI.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISO:MGI.
DR InterPro; IPR007265; COG_su3.
DR PANTHER; PTHR13302; PTHR13302; 1.
DR Pfam; PF04136; Sec34; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..820
FT /note="Conserved oligomeric Golgi complex subunit 3"
FT /id="PRO_0000213501"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 655
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96JB2"
SQ SEQUENCE 820 AA; 93283 MW; FBB2D019E6DA6AA6 CRC64;
MAEAAAERDA REKLSLWDGR PDSMAPLTDR QTDSVLELKA AVENLPVPAE LPIEDVCSLA
SQSLPIELTA VVPDSTEDIL LKGFTSLGME EERIETAQQF FSWFAKLQTQ MDQDEGTKYR
QMRDYLSGFQ EQCDAILNDV NSALQHLESL QKQYLFVSNK TGTLHEACEQ LLKEQSELAD
LAEHIQQKLS YFNELETINT KLNSPTLSVN SEGFIPMLAK LDDCITYISS HPNFKDYPVY
LLKFKQCLSK ALHLMKTYTV NTLQTLTNQL LKRDPSSVPN ADNAFTLFYV KFRAAAPKVR
TLIEQIEQRS EKIPEYQHLL NDIHQCYLDQ RELLLGPSIA YTVTELTSQN NRDHCALVRS
GCAFMVHVCQ DEHQLYNEFF TKPTSKLDEL LEKLCVSLYD VFRPLIIHVI HLETLSELCG
ILKNEVLEDH VQHNAEQLGA FAAGVKQMLE DVQERLVYRT HIYIQTDITG YKPAPGDLAY
PDKLVMMEQI AQSLKDEQKK APSEASFSDV RLEEGEASGL RKSGSTDSLN PRPQTTISPA
DLHGMWYPTV RRTLVCLSKL YRCIDRAVFQ GLSQEALSAC IQSLLGASES ISKNKTQIDG
QLFLIKHLLI LREQIAPFHT EFTIKEISLD LKKTRDAAFK ILNPMTVPRF FRLNSNNALI
EFLLEGTPEI REHYLDSKKD VDRHLKSACE QFIQQQTRLF GEQLEEFMTK VSALKTMASQ
GGPKYTLSQQ PWAQPAKVND LVATAYKTIK TKLPLTLRSM ALYLSNKDTE FILFKPVRNN
IQQVFQKFHA LLKEEFSSED IQIIACPSME QLNLLLSVSK
