ID   COG2_CAEEL              Reviewed;         681 AA.
AC   Q21444; Q17752;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 2;
DE            Short=COG complex subunit 2;
DE   AltName: Full=Component of oligomeric Golgi complex 2;
DE   AltName: Full=LDLC protein homolog;
GN   Name=cogc-2; Synonyms=cgo-2, cog-2, ldlc; ORFNames=C06G3.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7962052; DOI=10.1083/jcb.127.3.679;
RA   Podos S.D., Reddy P., Ashkenas J., Krieger M.;
RT   "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required
RT   for normal Golgi function.";
RL   J. Cell Biol. 127:679-691(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for normal Golgi morphology and function.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC       composed of eight different subunits and is required for normal Golgi
CC       morphology and localization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG2 family. {ECO:0000305}.
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DR   EMBL; Z34976; CAA84428.1; -; mRNA.
DR   EMBL; FO080396; CCD83558.1; -; Genomic_DNA.
DR   PIR; B53542; B53542.
DR   PIR; T30098; T30098.
DR   RefSeq; NP_501092.1; NM_068691.5.
DR   AlphaFoldDB; Q21444; -.
DR   SMR; Q21444; -.
DR   BioGRID; 42592; 5.
DR   DIP; DIP-26998N; -.
DR   IntAct; Q21444; 4.
DR   STRING; 6239.C06G3.10; -.
DR   EPD; Q21444; -.
DR   PaxDb; Q21444; -.
DR   PeptideAtlas; Q21444; -.
DR   EnsemblMetazoa; C06G3.10.1; C06G3.10.1; WBGene00000585.
DR   GeneID; 177473; -.
DR   KEGG; cel:CELE_C06G3.10; -.
DR   UCSC; C06G3.10; c. elegans.
DR   CTD; 177473; -.
DR   WormBase; C06G3.10; CE28817; WBGene00000585; cogc-2.
DR   eggNOG; KOG2307; Eukaryota.
DR   GeneTree; ENSGT00390000012040; -.
DR   HOGENOM; CLU_451516_0_0_1; -.
DR   InParanoid; Q21444; -.
DR   OMA; TFIDKCM; -.
DR   OrthoDB; 190117at2759; -.
DR   PhylomeDB; Q21444; -.
DR   Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR   PRO; PR:Q21444; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00000585; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0035262; P:gonad morphogenesis; IMP:WormBase.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
DR   InterPro; IPR009316; COG2.
DR   InterPro; IPR024603; COG_complex_COG2_C.
DR   InterPro; IPR024602; COG_su2_N.
DR   PANTHER; PTHR12961; PTHR12961; 1.
DR   Pfam; PF06148; COG2; 1.
DR   Pfam; PF12022; DUF3510; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..681
FT                   /note="Conserved oligomeric Golgi complex subunit 2"
FT                   /id="PRO_0000213497"
SQ   SEQUENCE   681 AA;  78564 MW;  CBD28125D1B3205C CRC64;
     MGTLHGEKTM FASPNTFYID ESKLCFNKTH FNREDFNVER FMNLARQKSD LKTIQQDLRL
     YLKSVQNSMI ELINDDYADF VHLSSNLVSL QDSLNKIEQD INRIWDEFKE STRESVGMAE
     RIEQKCDELC SNREKQIEIR DRIYFLVAIE KLSEMLLHPP RKCSALWLQK AASFASELKG
     STFPHSEEEN AAEKIILSQL EAVLCAEGVR SAAGDCQNLP LIYSILSLTE STHSLTALLV
     SDLLYAEFVN EKHDESNQLK LLKQVFESVK KMRETWAEKM GTEHFRGNIR RFLDETLLTF
     ILTFIDKCMG AVAVPSDTRL FHECFLLTQE FIDNWPSSHT CRAMLKSIRD KFNLLVYFKL
     ETHRFGKQCD QLMSPEMFAE PETSENRENT PQLHCGVSRA IITAIEHVWS DDVYLPPIVD
     KLWDFTLKLL LKHFSWSQTM KNYFMEEKRD WTSMVTLRSD TGNLHQLVFD FALESIWGKF
     HDITVDTAPF GQCLTKHGRS IDSLCVQIDD SIIEMFSEVL HQEIAQVSDV PKQYRWTKKS
     PPTTHSKYVV TAIEMVENLK EKLCCEEHPH TDEIVRKVNL SAFNYFVGKG NEVLDSVEAT
     GSSLSRFKRK TTTDSGSTVT DDDKIKQQIY HDAKYFLSYA ENLVFSQADL TGLQEVVNRF
     DKDARSAIVQ EKNQNEEAGN A