CMTA2_MOUSE
ID CMTA2_MOUSE Reviewed; 1208 AA.
AC Q80Y50; B0QZH5; Q3TFK0; Q5SX54; Q5SX68; Q6PHS5; Q80TP1; Q8R0D9; Q8R2N5;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Calmodulin-binding transcription activator 2;
GN Name=Camta2; Synonyms=Kiaa0909;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Embryonic heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
RC STRAIN=C57BL/6J; TISSUE=Brain, Eye, Mammary gland, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-1208 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
CC -!- FUNCTION: Transcription activator. May act as tumor suppressor (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: May interact with calmodulin. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q80Y50-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80Y50-2; Sequence=VSP_018496;
CC Name=3;
CC IsoId=Q80Y50-3; Sequence=VSP_018494, VSP_018496, VSP_018499;
CC Name=4;
CC IsoId=Q80Y50-4; Sequence=VSP_018495, VSP_018499;
CC Name=5;
CC IsoId=Q80Y50-5; Sequence=VSP_018497, VSP_018498;
CC -!- SIMILARITY: Belongs to the CAMTA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK169118; BAE40898.1; -; mRNA.
DR EMBL; AL596117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR933735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR933736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027039; AAH27039.1; -; mRNA.
DR EMBL; BC027385; AAH27385.1; -; mRNA.
DR EMBL; BC049133; AAH49133.1; -; mRNA.
DR EMBL; BC056395; AAH56395.1; -; mRNA.
DR EMBL; AK122400; BAC65682.1; -; mRNA.
DR CCDS; CCDS24963.1; -. [Q80Y50-1]
DR CCDS; CCDS56786.1; -. [Q80Y50-4]
DR CCDS; CCDS56788.1; -. [Q80Y50-2]
DR RefSeq; NP_001177305.1; NM_001190376.1. [Q80Y50-2]
DR RefSeq; NP_001177308.1; NM_001190379.1. [Q80Y50-4]
DR RefSeq; NP_835217.1; NM_178116.4. [Q80Y50-1]
DR AlphaFoldDB; Q80Y50; -.
DR SMR; Q80Y50; -.
DR STRING; 10090.ENSMUSP00000043792; -.
DR iPTMnet; Q80Y50; -.
DR PhosphoSitePlus; Q80Y50; -.
DR PaxDb; Q80Y50; -.
DR PRIDE; Q80Y50; -.
DR ProteomicsDB; 283319; -. [Q80Y50-1]
DR ProteomicsDB; 283320; -. [Q80Y50-2]
DR ProteomicsDB; 283321; -. [Q80Y50-3]
DR ProteomicsDB; 283322; -. [Q80Y50-4]
DR ProteomicsDB; 283323; -. [Q80Y50-5]
DR Antibodypedia; 53152; 28 antibodies from 19 providers.
DR DNASU; 216874; -.
DR Ensembl; ENSMUST00000036299; ENSMUSP00000043792; ENSMUSG00000040712. [Q80Y50-1]
DR Ensembl; ENSMUST00000100933; ENSMUSP00000098493; ENSMUSG00000040712. [Q80Y50-3]
DR Ensembl; ENSMUST00000108544; ENSMUSP00000104184; ENSMUSG00000040712. [Q80Y50-2]
DR Ensembl; ENSMUST00000108545; ENSMUSP00000104185; ENSMUSG00000040712. [Q80Y50-4]
DR GeneID; 216874; -.
DR KEGG; mmu:216874; -.
DR UCSC; uc007jwa.2; mouse. [Q80Y50-4]
DR UCSC; uc007jwc.2; mouse. [Q80Y50-1]
DR UCSC; uc007jwd.2; mouse. [Q80Y50-2]
DR CTD; 23125; -.
DR MGI; MGI:2135957; Camta2.
DR VEuPathDB; HostDB:ENSMUSG00000040712; -.
DR eggNOG; KOG0520; Eukaryota.
DR GeneTree; ENSGT00940000160105; -.
DR HOGENOM; CLU_003170_2_0_1; -.
DR InParanoid; Q80Y50; -.
DR OMA; NPHLTQH; -.
DR OrthoDB; 315169at2759; -.
DR PhylomeDB; Q80Y50; -.
DR TreeFam; TF323452; -.
DR BioGRID-ORCS; 216874; 5 hits in 76 CRISPR screens.
DR ChiTaRS; Camta2; mouse.
DR PRO; PR:Q80Y50; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q80Y50; protein.
DR Bgee; ENSMUSG00000040712; Expressed in primary visual cortex and 65 other tissues.
DR ExpressionAtlas; Q80Y50; baseline and differential.
DR Genevisible; Q80Y50; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003682; F:chromatin binding; ISO:MGI.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0003713; F:transcription coactivator activity; ISO:MGI.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043661; Camta2.
DR InterPro; IPR005559; CG-1_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR23335:SF9; PTHR23335:SF9; 4.
DR Pfam; PF03859; CG-1; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM01076; CG-1; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS51437; CG_1; 1.
DR PROSITE; PS50096; IQ; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; ANK repeat; DNA-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..1208
FT /note="Calmodulin-binding transcription activator 2"
FT /id="PRO_0000235822"
FT DOMAIN 544..622
FT /note="IPT/TIG"
FT REPEAT 717..750
FT /note="ANK 1"
FT REPEAT 762..792
FT /note="ANK 2"
FT REPEAT 796..826
FT /note="ANK 3"
FT DOMAIN 1054..1083
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1107..1136
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DNA_BIND 30..160
FT /note="CG-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00767"
FT REGION 269..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 78..86
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00767"
FT COMPBIAS 272..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..480
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..10
FT /note="MNTKDTTEVA -> MAAAAVTRGTPG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_018494"
FT VAR_SEQ 114..142
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_018495"
FT VAR_SEQ 114..118
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:12693553,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16141072"
FT /id="VSP_018496"
FT VAR_SEQ 913..1001
FT /note="APSPCGPPLAQDNGAAPEDADSPPAVDVIPVDMISLAKQIIDATPERIKRED
FT FSEFPDAGASPREHTGTVGLSETMSWLASYLENVDHF -> PPPGLTRFLPSGCASSFG
FT LRLQKTHAPHICIFSCDLRSPACTFSISPFLPAPDSDLPDLPYLFVRESLMNVSASVPT
FT AAFAARALVFQG (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018497"
FT VAR_SEQ 1002..1208
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018498"
FT VAR_SEQ 1094..1100
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_018499"
FT CONFLICT 235
FT /note="S -> G (in Ref. 1; BAE40898)"
FT /evidence="ECO:0000305"
FT CONFLICT 545
FT /note="F -> L (in Ref. 1; BAE40898)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1208 AA; 132010 MW; F32D05F8C5A3590C CRC64;
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY LITFEKHDEW
LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT REDHMKLKVQ GMEPVSWQCL
YGCYVHSSIV PTFHRRCYWL LQNPDIVLVH YLNVPALEDC GKGCSPIFCS ISSDRREWLK
WSREELLGQL KPMFHGIKWS CGNGAEEFSV EQLVQQILDT HPTKPAPRTH ACLCSGGLGS
GSLTHKCSST KHRIISPKVE PRALALASIS HSKPPEPPPL IAPLPPELPK AHTSPSSSSS
SSSSSGFAEP LEIRPSPPTS RGGSSRGGTA ILLLTGLEQR AGGLTPTRHL APQAEPRPPV
SLAVVVGSEP SAPPAPPSPA FDPDRFLNSP QRGQTYGGGQ GVNPDFPEAE GTHTPCPALE
PAAALEPQAA ARGLAPQLGA NGRRGNKFFI QDDDSGEELK GPGTVPPVPS SPPSSPSSPT
ALPPSGRATR GEALFGGSAG SSSELEPFSL SSFPDLMGEL ISDEAPGVPA PAPQLSPALN
AITDFSPEWS YPEGGVKVLI TGPWTEAAEH YSCVFDHIAV PASLVQPGVL RCYCPAHEVG
LVSLQVAGRE GPLSASVLFE YRARRFLSLP STQLDWLSLD DSQFRMSILE RLEQMEKRMA
EIAAAGQAPG QGPEAPPIQD EGQGPGFEAR VVVLVESMIP RSTWRGPERL IHGSPFRGMS
LLHLAAAQGY ARLIETLSQW RSVETGSLDL EQEVDPLNVD HFSCTPLMWA CALGHLEAAV
LLFCWNRQAL SIPDSLGRLP LSVAHSRGHV RLARCLEELQ RQELSVEHPL ALSPPSSSPD
TGLSSASSPS ELSDGTFSVT SAYSSAPDGS PPPAPPLASD ISMEMIPGQL SCGAPETPLL
LMDYEATNSK EPAPSPCGPP LAQDNGAAPE DADSPPAVDV IPVDMISLAK QIIDATPERI
KREDFSEFPD AGASPREHTG TVGLSETMSW LASYLENVDH FPSSAPPSEL PFERGRLAIP
PAPSWAEFLS ASTSGKMESD FALLTLSDHE QRELYEAARV IQTAFRKYKG RRLKEQQEVA
AAVIQRCYRK YKQLTWIALK FALYKKMTQA AILIQSKFRS YYEQKRFQQS RRAAVLIQQH
YRSYRRRPGP PHRPSGPLPA RNKGTFLTKK QDQAARKIMR FLRRCRHRMR ELKQNQELEG
LPQPGLAT
