ID   CLP1_HERIL              Reviewed;          69 AA.
AC   L7VIN3;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Cecropin-like peptide 1 {ECO:0000303|Ref.1};
DE            Short=CLP1 {ECO:0000303|Ref.1};
DE   Flags: Precursor;
OS   Hermetia illucens (Black soldier fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Stratiomyomorpha;
OC   Stratiomyidae; Hermetiinae; Hermetia.
OX   NCBI_TaxID=343691 {ECO:0000312|EMBL:AGC65588.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-40, FUNCTION,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, MASS SPECTROMETRY, AND
RP   AMIDATION AT GLN-68.
RC   TISSUE=Fat body {ECO:0000303|Ref.1}, and Hemolymph {ECO:0000303|Ref.1};
RX   DOI=10.1111/1748-5967.12226;
RA   Park S.-I., Yoe S.M.;
RT   "A novel cecropin-like peptide from black soldier fly, Hermetia illucens:
RT   Isolation, structural and functional characterization.";
RL   Entomol. Res. 47:115-124(2017).
CC   -!- FUNCTION: Antimicrobial peptide active against Gram-negative bacteria
CC       E.coli KCCM 11234 (MIC<=1.03 uM), E.aerogenes KCCM 12177 (MIC<=2.07 uM)
CC       and P.aeruginosa KCCM 11328 (MIC<=2.07 uM). Not active against various
CC       Gram-positive bacteria at concentrations up to 4.14 uM.
CC       {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Following bacterial infection, expressed in fat
CC       body, trachea and muscle. {ECO:0000269|Ref.1}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=4840; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; JX997953; AGC65588.1; -; mRNA.
DR   AlphaFoldDB; L7VIN3; -.
DR   SMR; L7VIN3; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|Ref.1"
FT   CHAIN           24..68
FT                   /note="Cecropin-like peptide 1"
FT                   /evidence="ECO:0000305|Ref.1"
FT                   /id="PRO_0000441216"
FT   MOD_RES         68
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   69 AA;  7373 MW;  E3207FECC3CF8F81 CRC64;
     MNFTKLFVVF AVVLVAFAGQ SEAGWRKRVF KPVEKFGQRV RDAGVQGIAI AQQGANVLAT
     ARGGPPQQG