CLP1_DROYA
ID CLP1_DROYA Reviewed; 423 AA.
AC B4P4H2;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN Name=cbc; ORFNames=GE13359;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR EMBL; CM000158; EDW90611.1; -; Genomic_DNA.
DR RefSeq; XP_002090899.1; XM_002090863.2.
DR AlphaFoldDB; B4P4H2; -.
DR SMR; B4P4H2; -.
DR STRING; 7245.FBpp0258369; -.
DR EnsemblMetazoa; FBtr0259877; FBpp0258369; FBgn0231038.
DR GeneID; 6529944; -.
DR KEGG; dya:Dyak_GE13359; -.
DR eggNOG; KOG2749; Eukaryota.
DR HOGENOM; CLU_018195_1_0_1; -.
DR OMA; VQYVNCH; -.
DR OrthoDB; 814241at2759; -.
DR PhylomeDB; B4P4H2; -.
DR Proteomes; UP000002282; Chromosome 2R.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:EnsemblMetazoa.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR Gene3D; 2.40.30.330; -; 1.
DR Gene3D; 2.60.120.1030; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; mRNA processing; Nucleotide-binding; Nucleus.
FT CHAIN 1..423
FT /note="Protein CLP1 homolog"
FT /id="PRO_0000375188"
FT BINDING 16
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 119..124
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ SEQUENCE 423 AA; 46767 MW; D502F0B90BC482C3 CRC64;
MSEDHGKDYT LEADSELRFE IEQKDAKVLV SLVSGFAELF GTELVKKKQY EFGMGAKVAI
FTYQGCVLHV SGKMDVCYIS KETPMVQYVN CHAALEQFRM EAEEKDRHGP VAMVVGPMDV
GKSTLCRILL NYAVRVGRRP LYADLDVGQG SIAIAGSVAT ILIERPANVE EGFAKTAPLV
YHFGHKSPSG NSILYNAVVS KMAEVTLHSL NSNKRTKSSG IIVNTCGWVK GSGYAHLLHA
AKAYGACAIF VLDQERLYNE LLRDVPKGVH VVLLPKSGGV VERSKELRHE ARDQRIKEYF
YGNARAPFYP FSFEVKFQDL RLYKIGAPPL PDSCMPIGMK AEDNKTKVVA VTPTPALIHH
VLALSFAESV EDEVIGTNVA GFCCVTEVDM ERQAVMLLSP QPRPLPPNAL LLWSELQFMD
NHT
