CLN8_RAT
ID CLN8_RAT Reviewed; 288 AA.
AC Q6AYM9;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Protein CLN8;
GN Name=Cln8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could play a role in cell proliferation during neuronal
CC differentiation and in protection against cell death.
CC {ECO:0000250|UniProtKB:Q9UBY8}.
CC -!- SUBUNIT: Interacts with CLN5. Interacts with CLN3 (By similarity).
CC {ECO:0000250|UniProtKB:Q9QUK3, ECO:0000250|UniProtKB:Q9UBY8}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9UBY8}; Multi-pass membrane protein
CC {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment
CC membrane {ECO:0000250|UniProtKB:Q9UBY8}; Multi-pass membrane protein
CC {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9UBY8}.
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DR EMBL; BC078982; AAH78982.1; -; mRNA.
DR RefSeq; NP_001007687.1; NM_001007686.1.
DR RefSeq; XP_006253456.1; XM_006253394.3.
DR AlphaFoldDB; Q6AYM9; -.
DR STRING; 10116.ENSRNOP00000016756; -.
DR PaxDb; Q6AYM9; -.
DR Ensembl; ENSRNOT00000016756; ENSRNOP00000016756; ENSRNOG00000012565.
DR GeneID; 306619; -.
DR KEGG; rno:306619; -.
DR UCSC; RGD:1359518; rat.
DR CTD; 2055; -.
DR RGD; 1359518; Cln8.
DR eggNOG; KOG4561; Eukaryota.
DR GeneTree; ENSGT01010000222313; -.
DR HOGENOM; CLU_951678_0_0_1; -.
DR InParanoid; Q6AYM9; -.
DR OMA; FFRTFDL; -.
DR OrthoDB; 1354968at2759; -.
DR PhylomeDB; Q6AYM9; -.
DR TreeFam; TF331146; -.
DR PRO; PR:Q6AYM9; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000012565; Expressed in spleen and 20 other tissues.
DR Genevisible; Q6AYM9; RN.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0097001; F:ceramide binding; ISS:UniProtKB.
DR GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR GO; GO:0007628; P:adult walking behavior; ISO:RGD.
DR GO; GO:0001306; P:age-dependent response to oxidative stress; ISO:RGD.
DR GO; GO:0008306; P:associative learning; ISO:RGD.
DR GO; GO:0044265; P:cellular macromolecule catabolic process; ISO:RGD.
DR GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR GO; GO:0008203; P:cholesterol metabolic process; ISS:UniProtKB.
DR GO; GO:0051935; P:glutamate reuptake; ISO:RGD.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR GO; GO:0007040; P:lysosome organization; ISO:RGD.
DR GO; GO:0007006; P:mitochondrial membrane organization; ISO:RGD.
DR GO; GO:0050881; P:musculoskeletal movement; ISO:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR GO; GO:0060052; P:neurofilament cytoskeleton organization; ISO:RGD.
DR GO; GO:0050885; P:neuromuscular process controlling balance; ISO:RGD.
DR GO; GO:0050884; P:neuromuscular process controlling posture; ISO:RGD.
DR GO; GO:0006644; P:phospholipid metabolic process; ISS:UniProtKB.
DR GO; GO:0045494; P:photoreceptor cell maintenance; ISO:RGD.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0008361; P:regulation of cell size; ISO:RGD.
DR GO; GO:0060041; P:retina development in camera-type eye; ISO:RGD.
DR GO; GO:0097473; P:retinal rod cell apoptotic process; IEA:Ensembl.
DR GO; GO:0035176; P:social behavior; ISO:RGD.
DR GO; GO:0021523; P:somatic motor neuron differentiation; ISO:RGD.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; ISO:RGD.
DR GO; GO:0007601; P:visual perception; ISO:RGD.
DR InterPro; IPR006634; TLC-dom.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..288
FT /note="Protein CLN8"
FT /id="PRO_0000185539"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 62..262
FT /note="TLC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
FT MOTIF 285..288
FT /note="ER-retrieval signal"
FT /evidence="ECO:0000250"
SQ SEQUENCE 288 AA; 33120 MW; D801BE0285F289B7 CRC64;
MTPVSNHGVA ESIFDLDYAS WKIRSTLAVA GFVFYLGVFV VCHQLSSSLN ATYRSLLAKE
KVFWNLAATR AVFGIQSTAA GLWALLGDPV LYSNKALGQQ NWCWFHITTA TGFFFFENAA
VHLSNLFFRT FDLFLVVHHL FAFLGFLGSA VNLRAGHYLA MTTLLLEMST PFTCVSWMLL
KAGWSHSLFW KVNQWLMIHM FHCRMILTYH MWWVCFQHWD ALASSLYLPH LALFLFGLAL
LTVIINPYWT HKKTQQLLNP VDWNFAQPEA KGDRQERTNG QVPRKKRL
