ID   CLN6_CANLF              Reviewed;         312 AA.
AC   Q5JZQ8;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Ceroid-lipofuscinosis neuronal protein 6 homolog;
DE            Short=Protein CLN6;
GN   Name=CLN6;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Droegemueller C., Woehlke A., Distl O.;
RT   "Characterization of candidate genes for neuronal ceroid lipofuscinosis in
RT   Tibetan terrier dogs.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with CRMP2. Interacts with CLN5 (By similarity).
CC       Interacts with CLN5. Interacts with CLN3 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9NWW5}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9NWW5}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9NWW5}.
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DR   EMBL; AJ875418; CAI44939.1; -; mRNA.
DR   RefSeq; NP_001011888.1; NM_001011888.1.
DR   AlphaFoldDB; Q5JZQ8; -.
DR   STRING; 9612.ENSCAFP00000025751; -.
DR   PaxDb; Q5JZQ8; -.
DR   Ensembl; ENSCAFT00000027690; ENSCAFP00000025751; ENSCAFG00000017473.
DR   Ensembl; ENSCAFT00030019914; ENSCAFP00030017357; ENSCAFG00030010614.
DR   Ensembl; ENSCAFT00040048353; ENSCAFP00040042233; ENSCAFG00040025859.
DR   Ensembl; ENSCAFT00845033654; ENSCAFP00845026347; ENSCAFG00845018935.
DR   GeneID; 497068; -.
DR   CTD; 54982; -.
DR   VEuPathDB; HostDB:ENSCAFG00845018935; -.
DR   VGNC; VGNC:39351; CLN6.
DR   eggNOG; ENOG502QSUV; Eukaryota.
DR   GeneTree; ENSGT00400000022240; -.
DR   InParanoid; Q5JZQ8; -.
DR   OrthoDB; 1081916at2759; -.
DR   Proteomes; UP000002254; Chromosome 30.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0035727; F:lysophosphatidic acid binding; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0120146; F:sulfatide binding; ISS:UniProtKB.
DR   GO; GO:0044265; P:cellular macromolecule catabolic process; IEA:Ensembl.
DR   GO; GO:0008203; P:cholesterol metabolic process; ISS:UniProtKB.
DR   GO; GO:0001573; P:ganglioside metabolic process; ISS:UniProtKB.
DR   GO; GO:0030203; P:glycosaminoglycan metabolic process; ISS:UniProtKB.
DR   GO; GO:0031987; P:locomotion involved in locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007042; P:lysosomal lumen acidification; ISS:UniProtKB.
DR   GO; GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.
DR   GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR   InterPro; IPR029255; CLN6.
DR   PANTHER; PTHR16244; PTHR16244; 1.
DR   Pfam; PF15156; CLN6; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Ceroid-lipofuscinosis neuronal protein 6 homolog"
FT                   /id="PRO_0000089861"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  35817 MW;  F2B044A8201AB2ED CRC64;
     MEAAARRRQH PGAAGGAGAQ PGASFLQARH SSGKADEAVG TAPFHLDLWF YFTLQNWVLD
     FGRPIAMLVF PLEWFPLNKP SVGDYFHMAY NIITPFLLLK LIERSPRTLP RSVIYVSIIT
     FVMGASIHLV GDSVNHRLLF SGYQHHLSVR ENPIIKNLSP ETLIDSFELL YYYDEYLGHC
     MWYVPFFLIL FIYFSGCFTP TKAESSMPGA ALLLAMPSGL YYWYLVTEGQ IFILFIFTFF
     AMLALVLHQK RKRLFLDSNG LFLFYSFALT LLLVALWVAW LWNDPVLRKK YPGVIYVPEP
     WAFYTLHVSS RP