CLN5_DICDI
ID CLN5_DICDI Reviewed; 322 AA.
AC Q553W9; Q86I57; Q86I58;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Ceroid-lipofuscinosis neuronal protein 5 homolog;
DE Short=Protein CLN5;
DE Flags: Precursor;
GN Name=cln5; ORFNames=DDB_G0275299;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the CLN5 family. {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69930.1; -; Genomic_DNA.
DR RefSeq; XP_643842.1; XM_638750.1.
DR AlphaFoldDB; Q553W9; -.
DR SMR; Q553W9; -.
DR STRING; 44689.DDB0234077; -.
DR PaxDb; Q553W9; -.
DR EnsemblProtists; EAL69930; EAL69930; DDB_G0275299.
DR GeneID; 8619889; -.
DR KEGG; ddi:DDB_G0275299; -.
DR dictyBase; DDB_G0275299; cln5.
DR eggNOG; ENOG502QPQ5; Eukaryota.
DR HOGENOM; CLU_050387_0_0_1; -.
DR InParanoid; Q553W9; -.
DR OMA; FRPHQSF; -.
DR PhylomeDB; Q553W9; -.
DR PRO; PR:Q553W9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005938; C:cell cortex; IDA:dictyBase.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:dictyBase.
DR GO; GO:0005576; C:extracellular region; IDA:dictyBase.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:dictyBase.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IDA:dictyBase.
DR GO; GO:0006914; P:autophagy; IMP:dictyBase.
DR GO; GO:0007155; P:cell adhesion; IMP:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0007040; P:lysosome organization; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR InterPro; IPR026138; CLN5.
DR PANTHER; PTHR15380; PTHR15380; 1.
DR Pfam; PF15014; CLN5; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..322
FT /note="Ceroid-lipofuscinosis neuronal protein 5 homolog"
FT /id="PRO_0000330473"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 37282 MW; 7BA31574556B01E8 CRC64;
MKRTIIILLF VSLFVTFVLS QIPDNDPELC QQRIQREDCP QTPVPWGTFN DNDEIEVYYM
QAPVFEAVFG NFFGKLGGYH SAIGFYDLTT GLNYTAEYDA FFEVGNGTLP NIINVDGKDE
LLWCNAGILC TVPYINETYW DKNIYSTASK TYMGTINGTQ LNQYIEWMQQ YNISNPVYQT
WDVWNNYGQD LFVPSTTCDD FTQQSIEHLG SIGINYNCST VFKRDYINLF TEKPQPIDFT
EHYDDIFKFY EAVLEIKEGS IAQIIERILS IIGLKKYIYV QGEYYLLELN YPFMNAKYDY
ITLPGCPANG IDYENGNFIH LN
