ID   CLMP_XENTR              Reviewed;         332 AA.
AC   Q640U3;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=CXADR-like membrane protein;
DE   AltName: Full=Adipocyte adhesion molecule;
DE   AltName: Full=Coxsackie- and adenovirus receptor-like membrane protein;
DE            Short=CAR-like membrane protein;
DE   Flags: Precursor;
GN   Name=clmp; Synonyms=acam, asam;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane
CC       {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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DR   EMBL; BC082496; AAH82496.1; -; mRNA.
DR   RefSeq; NP_001008177.1; NM_001008176.1.
DR   RefSeq; XP_012821936.1; XM_012966482.2.
DR   RefSeq; XP_012821937.1; XM_012966483.2.
DR   RefSeq; XP_012821938.1; XM_012966484.1.
DR   AlphaFoldDB; Q640U3; -.
DR   SMR; Q640U3; -.
DR   STRING; 8364.ENSXETP00000002682; -.
DR   PaxDb; Q640U3; -.
DR   DNASU; 493539; -.
DR   Ensembl; ENSXETT00000086152; ENSXETP00000084018; ENSXETG00000001242.
DR   GeneID; 493539; -.
DR   KEGG; xtr:493539; -.
DR   CTD; 79827; -.
DR   Xenbase; XB-GENE-973667; clmp.
DR   eggNOG; KOG3866; Eukaryota.
DR   InParanoid; Q640U3; -.
DR   OrthoDB; 995551at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000001242; Expressed in heart and 11 other tissues.
DR   ExpressionAtlas; Q640U3; baseline.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR042454; CLMP.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR44783; PTHR44783; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SMART; SM00406; IGv; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal;
KW   Tight junction; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..332
FT                   /note="CXADR-like membrane protein"
FT                   /id="PRO_0000293029"
FT   TOPO_DOM        20..231
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        253..332
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..123
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          130..220
FT                   /note="Ig-like C2-type 2"
FT   REGION          276..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..332
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        35..109
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        151..204
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   332 AA;  36852 MW;  0DF9DEB7D4BB426C CRC64;
     MHTLIRSFLG LWYVLGALAQ TEIKLVADEN VTLPCRHSLG HLGIQSLDIE WLSNISDHGK
     QVLLSYSGGQ VYNAENHKGR YSFVSKYLEG DASLFIRSLQ PSDAGQYICK VKNAGQYQWS
     FITVIVLVKP SELACSSEGA QLEGKNVTLN CKSTAGTKPL NYRWVRVNLK DNVERPVQST
     ARIGPENQLL LHNLSKTDNG SYRCEVSNEV GKRTCDVDVT VQSVSNTGIL AGVACGVVVG
     VFLIFFTVWL LFHKKEFKKR EEEEFFNEIR EDAEAPKARL VKPGSSSSDS RSSQSGSSST
     RSTTNSASRS QRTHSTQETP HGEQRHHCLE KI