CLMN_HUMAN
ID CLMN_HUMAN Reviewed; 1002 AA.
AC Q96JQ2; B2RAR7; Q9H713; Q9HA23; Q9HA57; Q9UFP4; Q9ULN2;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Calmin;
DE AltName: Full=Calponin-like transmembrane domain protein;
GN Name=CLMN; Synonyms=KIAA1188;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=11386753; DOI=10.1006/geno.2001.6544;
RA Ishisaki Z., Takaishi M., Furuta I., Huh N.-H.;
RT "Calmin, a protein with calponin homology and transmembrane domains
RT expressed in maturing spermatogenic cells.";
RL Genomics 74:172-179(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, Mammary gland, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-865.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 524-862, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis from
RT size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301; SER-619; THR-699;
RP SER-713; SER-769; SER-838 AND SER-841, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed at intermediate level.
CC {ECO:0000269|PubMed:10574461}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB13999.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB14036.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB14036.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
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DR EMBL; AB047979; BAB59010.1; -; mRNA.
DR EMBL; AK022279; BAB13999.1; ALT_INIT; mRNA.
DR EMBL; AK022445; BAB14036.1; ALT_SEQ; mRNA.
DR EMBL; AK025226; BAB15087.1; -; mRNA.
DR EMBL; CH471061; EAW81598.1; -; Genomic_DNA.
DR EMBL; AK314315; BAG36964.1; -; mRNA.
DR EMBL; AL117187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL117526; CAB55978.1; -; mRNA.
DR EMBL; AB033014; BAA86502.1; -; mRNA.
DR CCDS; CCDS9933.1; -.
DR PIR; T17288; T17288.
DR RefSeq; NP_079010.2; NM_024734.3.
DR AlphaFoldDB; Q96JQ2; -.
DR SMR; Q96JQ2; -.
DR BioGRID; 122889; 63.
DR IntAct; Q96JQ2; 6.
DR MINT; Q96JQ2; -.
DR STRING; 9606.ENSP00000298912; -.
DR GlyGen; Q96JQ2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96JQ2; -.
DR PhosphoSitePlus; Q96JQ2; -.
DR BioMuta; CLMN; -.
DR DMDM; 32699597; -.
DR EPD; Q96JQ2; -.
DR jPOST; Q96JQ2; -.
DR MassIVE; Q96JQ2; -.
DR MaxQB; Q96JQ2; -.
DR PaxDb; Q96JQ2; -.
DR PeptideAtlas; Q96JQ2; -.
DR PRIDE; Q96JQ2; -.
DR ProteomicsDB; 77004; -.
DR Antibodypedia; 1167; 52 antibodies from 14 providers.
DR DNASU; 79789; -.
DR Ensembl; ENST00000298912.9; ENSP00000298912.3; ENSG00000165959.12.
DR GeneID; 79789; -.
DR KEGG; hsa:79789; -.
DR MANE-Select; ENST00000298912.9; ENSP00000298912.3; NM_024734.4; NP_079010.2.
DR UCSC; uc001yef.3; human.
DR CTD; 79789; -.
DR DisGeNET; 79789; -.
DR GeneCards; CLMN; -.
DR HGNC; HGNC:19972; CLMN.
DR HPA; ENSG00000165959; Tissue enhanced (brain).
DR MIM; 611121; gene.
DR neXtProt; NX_Q96JQ2; -.
DR OpenTargets; ENSG00000165959; -.
DR PharmGKB; PA134945356; -.
DR VEuPathDB; HostDB:ENSG00000165959; -.
DR eggNOG; KOG0516; Eukaryota.
DR GeneTree; ENSGT00940000159056; -.
DR HOGENOM; CLU_014038_0_0_1; -.
DR InParanoid; Q96JQ2; -.
DR OMA; PHYEEEG; -.
DR OrthoDB; 543832at2759; -.
DR PhylomeDB; Q96JQ2; -.
DR TreeFam; TF317709; -.
DR PathwayCommons; Q96JQ2; -.
DR SignaLink; Q96JQ2; -.
DR BioGRID-ORCS; 79789; 12 hits in 1061 CRISPR screens.
DR ChiTaRS; CLMN; human.
DR GenomeRNAi; 79789; -.
DR Pharos; Q96JQ2; Tbio.
DR PRO; PR:Q96JQ2; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q96JQ2; protein.
DR Bgee; ENSG00000165959; Expressed in sperm and 185 other tissues.
DR ExpressionAtlas; Q96JQ2; baseline and differential.
DR Genevisible; Q96JQ2; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IBA:GO_Central.
DR GO; GO:0005640; C:nuclear outer membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR CDD; cd00014; CH; 2.
DR Gene3D; 1.10.418.10; -; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR Pfam; PF00307; CH; 2.
DR SMART; SM00033; CH; 2.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 1: Evidence at protein level;
KW Actin-binding; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1002
FT /note="Calmin"
FT /id="PRO_0000089854"
FT TRANSMEM 977..997
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT DOMAIN 32..139
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 187..291
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 1..288
FT /note="Actin-binding"
FT REGION 149..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 619
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 699
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 713
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 769
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 838
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 841
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 907
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C5W0"
FT VARIANT 963
FT /note="P -> L (in dbSNP:rs10149705)"
FT /id="VAR_050866"
FT CONFLICT 661
FT /note="A -> V (in Ref. 2; BAB13999)"
FT /evidence="ECO:0000305"
FT CONFLICT 866..868
FT /note="EKR -> KKK (in Ref. 2; BAB15087)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1002 AA; 111651 MW; D935F1744D76F0C4 CRC64;
MAAHEWDWFQ REELIGQISD IRVQNLQVER ENVQKRTFTR WINLHLEKCN PPLEVKDLFV
DIQDGKILMA LLEVLSGRNL LHEYKSSSHR IFRLNNIAKA LKFLEDSNVK LVSIDAAEIA
DGNPSLVLGL IWNIILFFQI KELTGNLSRN SPSSSLSPGS GGTDSDSSFP PTPTAERSVA
ISVKDQRKAI KALLAWVQRK TRKYGVAVQD FAGSWRSGLA FLAVIKAIDP SLVDMKQALE
NSTRENLEKA FSIAQDALHI PRLLEPEDIM VDTPDEQSIM TYVAQFLERF PELEAEDIFD
SDKEVPIEST FVRIKETPSE QESKVFVLTE NGERTYTVNH ETSHPPPSKV FVCDKPESMK
EFRLDGVSSH ALSDSSTEFM HQIIDQVLQG GPGKTSDISE PSPESSILSS RKENGRSNSL
PIKKTVHFEA DTYKDPFCSK NLSLCFEGSP RVAKESLRQD GHVLAVEVAE EKEQKQESSK
IPESSSDKVA GDIFLVEGTN NNSQSSSCNG ALESTARHDE ESHSLSPPGE NTVMADSFQI
KVNLMTVEAL EEGDYFEAIP LKASKFNSDL IDFASTSQAF NKVPSPHETK PDEDAEAFEN
HAEKLGKRSI KSAHKKKDSP EPQVKMDKHE PHQDSGEEAE GCPSAPEETP VDKKPEVHEK
AKRKSTRPHY EEEGEDDDLQ GVGEELSSSP PSSCVSLETL GSHSEEGLDF KPSPPLSKVS
VIPHDLFYFP HYEVPLAAVL EAYVEDPEDL KNEEMDLEEP EGYMPDLDSR EEEADGSQSS
SSSSVPGESL PSASDQVLYL SRGGVGTTPA SEPAPLAPHE DHQQRETKEN DPMDSHQSQE
SPNLENIANP LEENVTKESI SSKKKEKRKH VDHVESSLFV APGSVQSSDD LEEDSSDYSI
PSRTSHSDSS IYLRRHTHRS SESDHFSYVQ LRNAADLDDR RNRILTRKAN SSGEAMSLGS
HSPQSDSLTQ LVQQPDMMYF ILFLWLLVYC LLLFPQLDVS RL
