CLCA_DICDI
ID CLCA_DICDI Reviewed; 863 AA.
AC Q54AX6; Q95VF8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Chloride channel protein A;
GN Name=clcA; ORFNames=DDB_G0294096;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3-1;
RA Wang C.W., Liu C.I., Chang W.T.;
RT "Molecular analyses and functional studies of chloride channel protein ClcA
RT in Dictyostelium.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Voltage-gated chloride channel. Chloride channels may have
CC several functions including the regulation of cell volume, membrane
CC potential stabilization and signal transduction (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000305}.
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DR EMBL; AF414428; AAL07438.1; -; mRNA.
DR EMBL; AAFI02000006; EAL60414.1; -; Genomic_DNA.
DR RefSeq; XP_628848.1; XM_628846.1.
DR AlphaFoldDB; Q54AX6; -.
DR SMR; Q54AX6; -.
DR STRING; 44689.DDB0215359; -.
DR PaxDb; Q54AX6; -.
DR EnsemblProtists; EAL60414; EAL60414; DDB_G0294096.
DR GeneID; 8617995; -.
DR KEGG; ddi:DDB_G0294096; -.
DR dictyBase; DDB_G0294096; clcA.
DR eggNOG; KOG0474; Eukaryota.
DR HOGENOM; CLU_003181_4_1_1; -.
DR InParanoid; Q54AX6; -.
DR OMA; KEFHMST; -.
DR PhylomeDB; Q54AX6; -.
DR PRO; PR:Q54AX6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF81340; SSF81340; 1.
DR PROSITE; PS51371; CBS; 2.
PE 2: Evidence at transcript level;
KW CBS domain; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..863
FT /note="Chloride channel protein A"
FT /id="PRO_0000328043"
FT TOPO_DOM 1..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 539..559
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 661..742
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 816..863
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT REGION 48..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 97298 MW; 575CEE036AE0A435 CRC64;
MFRNNNNDNN NNDNGFDDEN KGIFLDSKIE ISDETSLIHK PYHDDYDENG LINNNNNSHN
NNNGGNNNNH GPSKVTHRRG KHTFTEADKL KMTKFESLDF PIIDNQIYRE YIRRTSKLNH
MLKTFGKWII CFMIGVLVGI TAYLVKQSVE FVNEFKFDQS GKYLEDERKF IAFLVYYSIN
ILFGVSASLV IIPVGQIASG SGIPEVKGYL NGIRIPQSMN VKTLVGKLVS LILAYSSGLI
LGPEGPMIHI GSMLGGAIGQ VKSKTLKWYP KVLWKYHNDR DRRDFISTGA AAGVAAAFGA
PIGGVLFGFE EASSFWSRQL TWRTFFACLI ATFTTNIILQ GFDMQLHDYG VLKFGLSNKY
LYKYSELIPF ALIGVAGGLF GALFVNLNAH LSQWRSKFFA NKKIYLRVLE VFILITITST
ILYCCAAFTP CRSKTQANGS QTNSLDTSSS SILSSSGDNS KNSTKLFKLL NNASGEDKQE
DKFIAFFCEQ GEYNQMAGLS FNSLDAALRL LFSTSTDIFT IPTLAVFSLI SFILTTITSG
LMLASGLFIP MMLVGATFGR LVGQVIALFV SVDPCIYALV GASAMMAGFS RMTISLAIIM
VELTEGTQYM LPVILSVMIA KWVGDFFNES IYEHLIEQKC YPFLQSQPPK SMIKLGVVDI
MKTEVVTLHE VERVSKVIEV LKSEQHFHNG FPVIERPRPL DPNRKDAYGN LEYYEDETTY
SGLILRNQLI CLLYYRIFCH EQPLPQNPRL LGGNSNRRYN QRRFGRPTEY GYAPADPRMT
YELMTQSLAR HFPPIDKMNL KKEEIETMYI DLRPYMNLST IVANETYSYS ETYSIFRTIG
LRHLPVVNKK NEVVGIVTRK DLL
