ID   CLCA3_HUMAN             Reviewed;         262 AA.
AC   Q9Y6N3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Calcium-activated chloride channel regulator family member 3;
DE            Short=Calcium-activated chloride channel family member 3;
DE            Short=hCLCA3;
DE   Flags: Precursor;
GN   Name=CLCA3P; Synonyms=CLCA3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, GLYCOSYLATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Spleen;
RX   PubMed=10095065; DOI=10.1016/s0167-4781(99)00008-1;
RA   Gruber A.D., Pauli B.U.;
RT   "Molecular cloning and biochemical characterization of a truncated,
RT   secreted member of the human family of Ca2+-activated Cl- channels.";
RL   Biochim. Biophys. Acta 1444:418-423(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10095065}.
CC   -!- TISSUE SPECIFICITY: Expressed in the lung, trachea, spleen, thymus and
CC       mammary gland. {ECO:0000269|PubMed:10095065}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:10095065}.
CC   -!- SIMILARITY: Belongs to the CLCR family. {ECO:0000305}.
CC   -!- CAUTION: In contrast to other members of the family, this protein is
CC       much shorter and lacks the VWFA domain. Defined as a pseudogene by
CC       HGNC. PubMed:10095065 reports that it is expressed and glycosylated in
CC       mammalian cells. {ECO:0000305}.
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DR   EMBL; AF043976; AAD23734.1; -; mRNA.
DR   AlphaFoldDB; Q9Y6N3; -.
DR   ChEMBL; CHEMBL2364708; -.
DR   TCDB; 1.A.13.1.4; the epithelial chloride channel (e-clc) family.
DR   GlyGen; Q9Y6N3; 2 sites.
DR   iPTMnet; Q9Y6N3; -.
DR   PhosphoSitePlus; Q9Y6N3; -.
DR   BioMuta; HGNC:2017; -.
DR   DMDM; 74721541; -.
DR   PRIDE; Q9Y6N3; -.
DR   GeneCards; CLCA3P; -.
DR   HGNC; HGNC:2017; CLCA3P.
DR   MIM; 604337; gene.
DR   neXtProt; NX_Q9Y6N3; -.
DR   InParanoid; Q9Y6N3; -.
DR   PhylomeDB; Q9Y6N3; -.
DR   PathwayCommons; Q9Y6N3; -.
DR   Reactome; R-HSA-2672351; Stimuli-sensing channels.
DR   Pharos; Q9Y6N3; Tdark.
DR   PRO; PR:Q9Y6N3; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q9Y6N3; protein.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; TAS:Reactome.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; TAS:Reactome.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013642; CLCA_N.
DR   Pfam; PF08434; CLCA; 1.
PE   1: Evidence at protein level;
KW   Calcium; Calcium channel; Calcium transport; Chloride; Chloride channel;
KW   Glycoprotein; Ion channel; Ion transport; Reference proteome; Secreted;
KW   Signal; Transport; Voltage-gated channel.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..262
FT                   /note="Calcium-activated chloride channel regulator family
FT                   member 3"
FT                   /id="PRO_0000306400"
FT   REGION          45..199
FT                   /note="Metalloprotease domain; probably inactive"
FT                   /evidence="ECO:0000250|UniProtKB:A8K7I4"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         84
FT                   /note="Y -> T (requires 2 nucleotide substitutions;
FT                   dbSNP:rs2292830)"
FT                   /id="VAR_035296"
FT   VARIANT         104
FT                   /note="I -> T (in dbSNP:rs2292829)"
FT                   /id="VAR_035297"
SQ   SEQUENCE   262 AA;  29971 MW;  D6C0E9F21300E33A CRC64;
     MVFSLKVILF LSLLLSPVLK SSLVTLNNNG YDGIVIAINP SVPEDEKLIQ NIKEMVTEAS
     THLFHATKQR AYFRNVSILI PMTYKSKSEY LIPKQETYDQ ADVIVADLYL KYGDDPYTLQ
     YGQCGDKGQY IHFTPNFLLT NNLATYGPRG KVFVHGWAHL RWGVFDEYNV DQPFYISRRN
     TTEATRCSTR ITVYMVLNEC KGASCIARPF RRDSQTGLYE AKCTFIPKRS QTAKESIVFM
     QNLDSVTEFC TEKTHNKEAP NL