CLC88_CAEEL
ID CLC88_CAEEL Reviewed; 228 AA.
AC Q86NG3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=C-type lectin domain-containing protein 88;
DE AltName: Full=Chondroitin proteoglycan 6;
DE Flags: Precursor;
GN Name=clec-88 {ECO:0000312|WormBase:K10B2.3a};
GN Synonyms=cpg-6 {ECO:0000312|EMBL:ABC65816.1}; ORFNames=K10B2.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABC65816.1}
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP GLYCOSYLATION AT SER-27.
RX PubMed=16785326; DOI=10.1083/jcb.200603003;
RA Olson S.K., Bishop J.R., Yates J.R., Oegema K., Esko J.D.;
RT "Identification of novel chondroitin proteoglycans in Caenorhabditis
RT elegans: embryonic cell division depends on CPG-1 and CPG-2.";
RL J. Cell Biol. 173:985-994(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-220, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
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DR EMBL; DQ340628; ABC65816.1; -; mRNA.
DR EMBL; FO080748; CCD66394.1; -; Genomic_DNA.
DR RefSeq; NP_495283.2; NM_062882.7.
DR AlphaFoldDB; Q86NG3; -.
DR SMR; Q86NG3; -.
DR STRING; 6239.K10B2.3b; -.
DR iPTMnet; Q86NG3; -.
DR EPD; Q86NG3; -.
DR PeptideAtlas; Q86NG3; -.
DR EnsemblMetazoa; K10B2.3a.1; K10B2.3a.1; WBGene00019606.
DR GeneID; 174056; -.
DR UCSC; K10B2.3a.1; c. elegans.
DR CTD; 174056; -.
DR WormBase; K10B2.3a; CE33419; WBGene00019606; clec-88.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00970000196041; -.
DR HOGENOM; CLU_093598_0_0_1; -.
DR InParanoid; Q86NG3; -.
DR PRO; PR:Q86NG3; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00019606; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q86NG3; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Lectin; Proteoglycan; Reference proteome;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..228
FT /note="C-type lectin domain-containing protein 88"
FT /evidence="ECO:0000255"
FT /id="PRO_0000320339"
FT DOMAIN 88..218
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 27
FT /note="O-linked (Xyl...) (chondroitin sulfate) serine"
FT /evidence="ECO:0000269|PubMed:16785326"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT DISULFID 109..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 188..209
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 228 AA; 26070 MW; 00C2ED5666DF96AF CRC64;
MQFIFFGTLF SGLLLVCAVT NDIEDASGET PGIVSQITEE QPHQRQKLYN WDYKDLGTIA
FEDIPFPTLQ PSQTIDQSEN CPEGWIRYSD SCYWVETELL GFAKAERKCS EKQSTLFVAN
SIDEWEAIRG HSKDSFSSWI GLVRFSHYER SEQLPRWQTE GAVNPSKINW LIKPYSPLVN
GWSQLANCAA SYKSPASLET ASYTYFYPCT YLFYSICERN STIANSLH
