CLASR_BOVIN
ID CLASR_BOVIN Reviewed; 670 AA.
AC A0JNI5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=CLK4-associating serine/arginine rich protein;
DE AltName: Full=Splicing factor, arginine/serine-rich 16;
GN Name=CLASRP; Synonyms=SFRS16;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probably functions as an alternative splicing regulator. May
CC regulate the mRNA splicing of genes such as CLK1. May act by regulating
CC members of the CLK kinase family (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Probably interacts with CLK4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- PTM: Phosphorylated in vitro by CLK4. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC126701; AAI26702.1; -; mRNA.
DR RefSeq; NP_001071355.1; NM_001077887.2.
DR AlphaFoldDB; A0JNI5; -.
DR STRING; 9913.ENSBTAP00000018204; -.
DR iPTMnet; A0JNI5; -.
DR PaxDb; A0JNI5; -.
DR PRIDE; A0JNI5; -.
DR Ensembl; ENSBTAT00000018204; ENSBTAP00000018204; ENSBTAG00000013697.
DR GeneID; 509208; -.
DR KEGG; bta:509208; -.
DR CTD; 11129; -.
DR VEuPathDB; HostDB:ENSBTAG00000013697; -.
DR VGNC; VGNC:27391; CLASRP.
DR eggNOG; KOG2548; Eukaryota.
DR GeneTree; ENSGT00940000153892; -.
DR HOGENOM; CLU_008114_1_0_1; -.
DR InParanoid; A0JNI5; -.
DR OMA; YSECAPV; -.
DR OrthoDB; 1620115at2759; -.
DR TreeFam; TF351621; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000013697; Expressed in retina and 104 other tissues.
DR ExpressionAtlas; A0JNI5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR040397; SWAP.
DR InterPro; IPR019147; SWAP_N_domain.
DR PANTHER; PTHR13161; PTHR13161; 2.
DR Pfam; PF09750; DRY_EERY; 1.
DR SMART; SM01141; DRY_EERY; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..670
FT /note="CLK4-associating serine/arginine rich protein"
FT /id="PRO_0000370322"
FT REGION 171..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 581..643
FT /evidence="ECO:0000255"
FT COMPBIAS 185..214
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..441
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..488
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 101
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N2M8"
FT MOD_RES 285
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N2M8"
FT MOD_RES 294
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N2M8"
FT MOD_RES 327
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N2M8"
FT MOD_RES 331
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N2M8"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N2M8"
FT MOD_RES 543
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N2M8"
FT MOD_RES 569
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N2M8"
SQ SEQUENCE 670 AA; 76791 MW; 9930DDC16AA2FE70 CRC64;
MWHEARKHER KLRGMMVDYK KRAERRREYY EKIKKDPAQF LQVHGRACKV HLDSAVALAA
ESPVNMMPWQ GDTNNMIDRF DVRAHLDHIP DYTPPLLTTI SPEQESDERK CNYERYRGLV
QNDFAGISEE QCLYQIYIDE LYGGLQRPSE DEKKKLAEKK ASIGYTYEDS TVAEVEKVTE
KPEEEESPAE EESNSDEDEV IPDIDVEVDV DELNQEQVAD LNKQATTYGM ADGDFVRMLR
KDKEEAEAIK HAKALEEEKA MYSGRRSRRQ RREFREKRLR GRKISPPSYA RRDSPTYDPY
KRSPSESSSE SRSRSRSPTP GREEKITFIT SFGGSDEEAA AAAAAAAASG AATGKPPAPP
QPGGPAPGRN ASARRRSSTS SSSSSASRTS SSRSRSSSSS RSRRGGGYYR SGRHARSRSR
SWSRSRSRSR RYSRSRSRGR RHSGGGSRDG HRYSRSPARR GGYGPRRRSR SRSRSGDRYR
RGGRGPRHHS SSRSSWSLSP SRSRSLTRSR SPSLSRSRSL SRSRSQSHSP SPPREKLSRP
AASPAVGEKL KKTEPAAGKE TGAAKPKLTP QEKLKLRMQK ALNRQFKADK KAAQEKMIQQ
EHERQEREDE LRAMARKIRM KERERREKER EEWERQYSRQ SRSPSPRYSR EYSSSRRRSR
SRSRSPHYRH
