ID   CLAP3_CAEEL             Reviewed;         983 AA.
AC   Q03609; P91845;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 3.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Protein CLASP-3;
GN   Name=cls-3; ORFNames=ZC84.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Microtubule plus-end tracking protein that promotes the
CC       stabilization of dynamic microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z19157; CAA79568.2; -; Genomic_DNA.
DR   PIR; C88550; C88550.
DR   PIR; S28293; S28293.
DR   PIR; S28294; S28294.
DR   RefSeq; NP_499034.2; NM_066633.4.
DR   AlphaFoldDB; Q03609; -.
DR   BioGRID; 41497; 5.
DR   STRING; 6239.ZC84.3; -.
DR   EPD; Q03609; -.
DR   PaxDb; Q03609; -.
DR   PeptideAtlas; Q03609; -.
DR   PRIDE; Q03609; -.
DR   EnsemblMetazoa; ZC84.3.1; ZC84.3.1; WBGene00013847.
DR   GeneID; 176298; -.
DR   UCSC; ZC84.3; c. elegans.
DR   CTD; 176298; -.
DR   WormBase; ZC84.3; CE43505; WBGene00013847; cls-3.
DR   eggNOG; KOG2956; Eukaryota.
DR   GeneTree; ENSGT00940000168069; -.
DR   HOGENOM; CLU_005060_1_0_1; -.
DR   InParanoid; Q03609; -.
DR   OMA; TLGDKDX; -.
DR   OrthoDB; 66632at2759; -.
DR   PhylomeDB; Q03609; -.
DR   PRO; PR:Q03609; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00013847; Expressed in embryo and 3 other tissues.
DR   GO; GO:0045180; C:basal cortex; IBA:GO_Central.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0030953; P:astral microtubule organization; IGI:WormBase.
DR   GO; GO:0040001; P:establishment of mitotic spindle localization; IGI:WormBase.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   InterPro; IPR034085; TOG.
DR   Pfam; PF12348; CLASP_N; 1.
DR   SMART; SM01349; TOG; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..983
FT                   /note="Protein CLASP-3"
FT                   /id="PRO_0000065496"
FT   REPEAT          918..956
FT                   /note="HEAT"
FT   REGION          356..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          666..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..387
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   983 AA;  108912 MW;  8B053DC2BD44F62B CRC64;
     MTSRMQPKSG VYSVSKADFT KIFEDVPKVP ITSAVDLRNK FDAVRIILSN SSEDWNKRQT
     QLKTVRSLVI HGEKVVDRPT MIAHLVQLLG CFELAVKDLR SQVLREAAIT CSFIVSKYGI
     ETHSIGEDIL VPAMSQVAVS TKIMATSAST LTEFIVEYVQ TRQVFTILSS FSTSKDKSQR
     RQLAALLEIV ISKWSDRIKK QIMRQICELI KSAINDADSE TRAAGRRAFA KLDEMHSEEA
     DALYLELDHS KQKMLRGGDA ASSWASVNSE KGSIPIRSKL SAGSKAHMNI SAKFLAQRSA
     SAIDPKATKF AGPSRLVRPT STKTMARQDT SPAGCKYSNF ISMFFKTLLL SAKIPYPNRP
     GSRTRTSSIT STDSRDTSPT RRNSPLPPET QKARVKYGNG SFFAKLGMPD TTDDDEFLLP
     IRIRSPLKTP TIEAHDKVSQ VLKECCSSSV SEKKEGIKKL LPIVADTSLN PIEIKNIGNC
     LNRLLSDASN TMVLEIYSIF VRTHSSRLSE WLRLALAKLF ARKAAETLPN TKKQIGHTLN
     VILECFNAHH QLVTVCELMC DPIHLMVPKA RVVLLEYLTS LLDEYTEPGA SINAKELKTA
     IRKMLTWASD PRLSILLTPH VEKAICSMFC VNVADFSALI SDLDSEQKNW IHQTLQRNGL
     ENGISSNNIA TNSGATASRE TSNTSFQKES TSFGLPEFGA RKGGTGVNLG SLNISNNLAL
     SRLEEQSTSR LMEKVNLNST VTLPPDTLEK IQNVQDLLQK MRSSENADEQ ESAISSIYMM
     ICDGGFGVWE QCYAKLLLNL FEILSKSRSE NNKKMCLRIL GKMCTAQAAK LFDSTEMAVC
     KVLDAAVNTN DATTALAVED CLRTLATHLP LSNIINIAKV ILNQEPIDDE RASLVLKMVT
     RLFEELPAEE LNNIVDDITP TIIKAYQSTS STVRKTVVYC LVAMVNRVGE QRMTPHFTKL
     PKAMTNLIQV YVNRAISTSL PRL