ID   CLAP3_CAEBR             Reviewed;         970 AA.
AC   Q61QN4; A8X3F5; E3CTZ4;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Protein CLASP-3;
GN   Name=cls-3; ORFNames=CBG06947;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Microtubule plus-end tracking protein that promotes the
CC       stabilization of dynamic microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
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DR   EMBL; HE601347; CBX33041.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q61QN4; -.
DR   STRING; 6238.CBG06947; -.
DR   WormBase; CBG06947; CBP44680; WBGene00029132; Cbr-cls-3.
DR   eggNOG; KOG2956; Eukaryota.
DR   HOGENOM; CLU_005060_1_0_1; -.
DR   InParanoid; Q61QN4; -.
DR   OMA; MKICDGG; -.
DR   OrthoDB; 66632at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0045180; C:basal cortex; IBA:GO_Central.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0040001; P:establishment of mitotic spindle localization; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   InterPro; IPR034085; TOG.
DR   Pfam; PF12348; CLASP_N; 1.
DR   SMART; SM01349; TOG; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..970
FT                   /note="Protein CLASP-3"
FT                   /id="PRO_0000272280"
FT   REPEAT          905..943
FT                   /note="HEAT"
FT   REGION          314..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          651..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..667
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   970 AA;  107506 MW;  373579BF26265470 CRC64;
     MTSRIQPKSG GYLLSKSDFT KVFEDVPKIA ITSSVDLRNK FDNVKTILSN TSEDWNKRQT
     QLKTIRSLII NGEKLVDRPT MIAHILQLLG CFELAVKDLR SQILREAAIT CSFIVSKYGI
     ETHSIGEDIL IPAMGQVAVS TKIMATSAST LTEFIVEYIQ TRQVFTILSS FSTSKDKNQR
     RQLAVLLEII IGKWSDRLKK QIIRQICELV KSAINDADSE TRAAGRRAFA KLEEFHSEEA
     DALFLELENS KQKMLRGGDA ASSWASINSD KGSIPIRSKL SAGAKGYSNI SAKFLAQRSA
     SAIDPKALKV TGPSRLARPL STKAMVRQDT SPAGSKIPYP NRPGSRTRTS SITSNDSRDT
     SPTRRHSPLP PDTQKARVKY GNGSFFAKLG MSDNTDDDEF LLPIRVRSPQ KPNLGDSPAD
     NVSRVLKECC SSSVTEKKDG IKKLLPIVSD TTLSSTEIKN IGNCLNRLLS DASNTKLILQ
     MVLEVYAVFI RTHSSRLSEW LRLALAKLFA RKATETLPNT KKQINHTLNV ILECFNAHHQ
     LVTVCELMCD PIHLMVPKAR VALLEYMTSL LDEYTEPGAS INHKELKAAL RKMFTWIGDQ
     RQSILLTPYI EKAICSMFCV NVADFSALIS EFDSDQKAWL HQTLQLNGLE NGISSGSGGS
     GNNHPKATPL RETPHKNDSV VLPEFGSAQK RTAINLGSFN TSTNAALSKL EEQSTSRLME
     KMNLNSTVTL PPDTLEKIQN VQDLLHKMRV SKDPDEQENA ISQVYMKICD GGFGIWEQCY
     AKLLLNLFEI LSTSRSENNK KMCLRILGKM CTAQAAKLFD STEMAVCKVL DAAVNTNDAT
     TALAVDDCLR TLATHLPLAN IINIAKVILI QEPIDDERAS LVLKMVTRLF EELPADELKN
     VVDDITPCVI KAYQSTSSSV RKTVVYCLVA MVNRVGEQRM APHFTKLPKA MTNLIQVYVN
     RAISTSLPRL