CLAP2_CAEBR
ID CLAP2_CAEBR Reviewed; 791 AA.
AC Q61J98; A8X9V7;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Protein CLASP-2;
DE Flags: Fragment;
GN Name=cls-2; ORFNames=CBG09877;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Probable microtubule plus-end tracking protein that promotes
CC the stabilization of dynamic microtubules. Required for the formation
CC of mitotic and meiotic spindles. Specifically promotes the
CC polymerization of kinetochore-bound microtubules. Also required for
CC cytoplasmic streaming (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hcp-1 and hcp-2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000250}. Note=Localized to kinetochores
CC during metaphase, and to the spindle region. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAP29422.3; Type=Erroneous gene model prediction; Note=The C-terminus of this protein appears likely to be in the unsequenced region.; Evidence={ECO:0000305};
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DR EMBL; HE601459; CAP29422.3; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q61J98; -.
DR SMR; Q61J98; -.
DR STRING; 6238.CBG09877; -.
DR PRIDE; Q61J98; -.
DR EnsemblMetazoa; CBG09877.1; CBG09877.1; WBGene00031391.
DR WormBase; CBG09877; CBP37613; WBGene00031391; Cbr-cls-2.
DR eggNOG; KOG2956; Eukaryota.
DR HOGENOM; CLU_005060_1_0_1; -.
DR InParanoid; Q61J98; -.
DR OMA; FSWMSDQ; -.
DR OrthoDB; 66632at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0045180; C:basal cortex; IBA:GO_Central.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0040001; P:establishment of mitotic spindle localization; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW Kinetochore; Meiosis; Microtubule; Mitosis; Reference proteome.
FT CHAIN 1..>791
FT /note="Protein CLASP-2"
FT /id="PRO_0000272279"
FT REGION 259..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 791
SQ SEQUENCE 791 AA; 87466 MW; 5ABA367EBBB0F50D CRC64;
MSRVVSRTVP GGACVVNKDD FLKSFNDVDK VSVSSLADAK SKFDQVIAIL SKSQEDWNKR
RTQLQIIRSI VINCEDVIGR DQLLGQLVRL ADCLDLSVKD LRSQILREAA ITCSFLFEKY
GNDVHQIAER CLPTAFSQLA VSTKVMATSG ATLTLFLVQY VQTKQIFTCL TTYSTSKDKN
QRRQLCVLLE IVIEHWNDKL KKSILPQIME LIKSAISDAD PETRAAGRKA FNKLDAIHSE
EADKLFASVD ANKQKMLRAS DAASSSTSVN SERGSAPFRS KLSAGSVGGM RNVPNISSKF
LAQRSASAID TKQVTRMTTS VSRTPNTRPM TTRTLSKVDT SPGGSKFARP TVGTLGPRTT
SNLRARGSVP TSQPGSRNGS PPRRPSTTGT LPMEMQRVKS NLGSSSFVSS LTPDQAESLQ
KAMNTAKESL GQPSRTEDDE FLLPKRKPKT PQKSAVDISR VEAVIRACVS TSANEKRDGI
KMLSIIVSEP NLSQIELKNI GQVLNRLLGE ATNPVVLESV ASFVKAHHSR LSEWLKLGLG
KMFAKKGSEM MPIMKKHIVT TINAILSSFD PALQLKATCE LMCDPIHLLS PKARVALLEY
LTDLLEKHME RGSPFNTKEV KATILKMFSW MSDQRNMQQI VPHGEKVLCG LFALNAADFS
ALFNDFNPDY REWAYRILQA HGHNQHAPAP ESPSPVRDQQ VRANISNTAA QIEDFVVARN
FELSAEKSPT SRGMLTSGFK RTDAEPLRPL ESDMNTQRMD DISINESFDR LKVRILETTG
FYAAFKVDFQ E
